1, 2 MR imaging of the head in 2011. The MRI T1Weighted Imaging shows that there is a irregular mass with equal T2 and a little bit long T1 signals in the left frontal-parietal lobe, which is close to the outer edge of the meninges and a large finger-like edema around the mass with the proof of the left lateral ventricle is pressed significantly and a 0.5 cm shift of the midline to the right side. (1) coronal plane; (2) sagittalia plane. 3, 4 Hymatoxylin and eosin (H&E) shows the morphologic features of the neoplastic cells. The neoplastic cells are large, round or oval, either diffused or sheet-spooty distributed, the cytoplasm is weak pink staining, some neoplastic cells like plasmatic cells with nuclei to one side, and some nuclei looks like “clock face” shape. Some cells shows coarse chromatin with smaller or unapparent nucleoli, but some cells have apparent nucleoli. The pathological mitosis and apoptosis are easy to find. (Magnification, ×400). 5–7 Immunohistochemistry staining shows the expression of LCA, CD38, CD79a in the tumor tissues. Positive IHC signals are visualized with brown yellow color (5) There are diffused LCA positive signals in the cytoplasm of a great number of neoplastic cells. (6) Extensive CD38 staining are detectable in numerous neoplastic cells. (5) Some neoplastic cells are identified using CD79a IHC staining. (Magnification, ×200). 8 In situ hybridization shows EBV EBER expression in the tumor tissues. Positive ISH signals are visualized with brown yellow color. There are significant positive siganals in most of the neoplastic cells. (Magnification, ×200).