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Table 2 Association of survivin and VEGF-C protein expression with clinicopathological features in breast cancer patients

From: Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer

Variable n Survivin- Survivin+ χ2 p VEGF-C - VEGF-C + χ2 p
Age     0 1    0.965 0.326
≤45 years 36 6 30    6 30   
>45 years 72 12 60    18 54   
Tumor size     9.305 0.01    4.102 0.129
T1 39 12 27    12 27   
T2 60 6 54    9 51   
T3 9 0 9    3 6   
Histological grade     0.873 0.350    0.175 0.675
I + II 99 15 84    21 78   
III 9 3 6    3 6   
Pathological style     0.169 0.681    0 1
ISC 12 3 9    3 9   
IC 96 15 81    21 75   
Lymph node metastasis     16.283 0.000    18.544 0.000
Negative 30 12 18    15 15   
Positive 78 6 72    9 69   
C-erBb-2     8.269 0.004    4.354 0.037
positive(3 + ) 12 6 6    6 6   
negative(0-2 + ) 96 12 84    18 78   
ER     0.617 0.432    0.882 0.348
positive 63 9 54    12 51   
negative 45 9 36    12 33   
PR     0 1    1.929 0.165
positive 54 9 45    15 39   
negative 54 9 45    9 45   
TNM stage     10.800 0.001    6.027 0.014
I, II 72 18 54    21 51   
III, IV 36 0 36    3 33   
  1. ISC, in situ carcinoma; IC, invasive carcinoma.