Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer

Diagnostic Pathology

Table 2 Association of survivin and VEGF-C protein expression with clinicopathological features in breast cancer patients

Variable	n	Survivin-	Survivin+	χ²	p	VEGF-C -	VEGF-C +	χ²	p
Age				0	1			0.965	0.326
≤45 years	36	6	30			6	30
>45 years	72	12	60			18	54
Tumor size				9.305	0.01			4.102	0.129
T1	39	12	27			12	27
T2	60	6	54			9	51
T3	9	0	9			3	6
Histological grade				0.873	0.350			0.175	0.675
I + II	99	15	84			21	78
III	9	3	6			3	6
Pathological style				0.169	0.681			0	1
ISC	12	3	9			3	9
IC	96	15	81			21	75
Lymph node metastasis				16.283	0.000			18.544	0.000
Negative	30	12	18			15	15
Positive	78	6	72			9	69
C-erBb-2				8.269	0.004			4.354	0.037
positive(3 + )	12	6	6			6	6
negative(0-2 + )	96	12	84			18	78
ER				0.617	0.432			0.882	0.348
positive	63	9	54			12	51
negative	45	9	36			12	33
PR				0	1			1.929	0.165
positive	54	9	45			15	39
negative	54	9	45			9	45
TNM stage				10.800	0.001			6.027	0.014
I, II	72	18	54			21	51
III, IV	36	0	36			3	33

ISSN: 1746-1596