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Figure 4 | Diagnostic Pathology

Figure 4

From: A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections

Figure 4

Differentiation of HER2 gene status in HER2 protein equivocal (IHC 2+) or negative (IHC 0) breast cancer tissues using the HER2 gene-protein assay. The HER2 gene-protein assay carried out on FFPE breast cancer tissue microarray slides was able to differentiate HER2 IHC 2+ cases that were HER2 & CEN17 BISH positive (A) and negative (B). It also distinguished HER2 IHC 0 cases that were HER2 & CEN17 BISH positive (C) and negative (D). [All images 100×.].

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