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Table 4 BISH descriptive statistics

From: A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections

 

Reader A

Reader B

Reader C

 

Gene-protein BISH (N = 183)

Single BISH (N = 183)

Gene-protein BISH (N = 183)

Single BISH (N = 183)

Gene-protein BISH (N = 183)

Single BISH (N = 183)

HER2 mean

n

179

166

179

172

180

173

Mean (SD)

4.273 (4.208)

4.643 (4.567)

5.199 (6.280)

5.452 (6.693)

3.333 (2.851)

3.176 (2.362)

Median

2.200

2.225

1.900

1.900

2.000

1.950

Min, max

1.00, 21.10

1.00, 22.60

1.00, 40.20

1.00, 40.40

1.00, 16.25

1.20, 11.10

CEN17 mean

n

179

166

179

172

180

173

Mean (SD)

1.803 (0.496)

1.868 (0.501)

1.566 (0.356)

1.540 (0.339)

1.606 (0.335)

1.613 (0.296)

Median

1.650

1.750

1.500

1.450

1.550

1.550

Min, max

1.00, 3.50

1.00, 3.95

1.00, 2.80

1.00, 2.95

1.05, 2.60

1.00, 2.65

HER2 /CEN17 ratio

n

179

166

179

172

180

173

Mean (SD)

2.485 (2.613)

2.521 (2.533)

3.344 (3.952)

3.637 (4.620)

2.100 (1.802)

2.004 (1.564)

Median

1.170

1.190

1.310

1.355

1.255

1.240

Min, max

0.67, 10.82

0.76, 11.02

0.67, 19.14

0.60, 26.06

0.74, 8.46

0.82, 9.25

Amplification status, n (%)

Amplified

46 (25.1)

46 (25.1)

49 (26.8)

50 (27.3)

47 (25.7)

43 (23.5)

Non-amplified

133 (72.7)

120 (65.6)

130 (71.0)

122 (66.7)

133 (72.7)

130 (71.0)

N/A

4 (2.2)

17 (9.3)

4 (2.2)

11 (6.0)

3 (1.6)

10 (5.5)

  1. BISH: brightfield in situ hybridization; HER2: human epidermal growth factor receptor 2; CEN17: chromosome 17 centromere.
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Diagnostic Pathology

ISSN: 1746-1596

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