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Table 1 Chromosomal alterations reported in carcinoma tissues from SMTC using CGH analysis

From: Genetic alterations in a primary medullary thyroid carcinoma and its lymph node metastasis in a patient with 15 years follow-up

Tissue n Ret mut Gains Losses Reference
SMTC primary tumor 10 Unknown 1q, 6, 7p, 11q, 21q 1p, 3q, 3, 13, 18p, 18q, 22 Hemmer et al., 1999 [18]
SMTC primary tumor 9 M918T 1p, 5p, 7q, 8q, 9q, 11q, 16, 19p, 19q, 22q 1p, 2q, 3q, 3, 4q, 9p + q, 10, 12p, 12q, 13q. Frisk et al., 2001 [16]
SMTC primary tumor 12 M918T 6p, 6, 7, 12p, 14q, 15q, 16, 19, X 1p, 3q, 3, 4q, 5q, 9, 11, 13q, 16p,16, 17p, 17, 19, 20q, 20, 22q, X Marsh et al., 2003 [19]
SMTC primary tumor 1 M918T 18p 6p , 16p Present case
SMTC metastasis 1 M918T 6 ,14q X Marsh et al., 2003 [19]
SMTC metastasis 1 M918T 2q, 3q, 4p + q, 5p + q, 6q, 8q, 12p + q, 13q, Xq 1p, 1q, 6p, 8p, 8q, 9q, 10p, 10q, 11q, 12q, 15q, 16, 17, 19, 20, and 22q Present case
  1. Note: n: number of cases studied; Ret mut: type of RET mutation; M918T: codon 918 (Met– > Thr). In bold letter the most common CGH gains and losses. Bold font indicates most common CGH imbalances reported by author.