Immunohistochemical characterization of neoplastic cells of breast origin

Diagnostic Pathology

Table 3 Immunohistochemical strategies, statistical results

	Strategy	TP	TN	FP	FN	S (%)	Sp (%)	PPV (%)	+LR	−LR
	Markers considered in a parallel manner
1	HR + CK7 + P-15	10	42	0	19	35	100	100	999.999	0.66
2	HR + CK7 + P-15 + MAG	7	42	0	22	24	100	100	999.999	0.76
	Markers considered in a serial manner
3	HR----CK7	28	20	22	1	97	48	56	1.84	0.07
4	HR----MAG	21	39	3	9	70	93	88	9.80	0.32
5	HR----MAG----CK7	28	22	20	1	97	52	58	2.03	0.07

HR: estrogen and progesterone receptors; CK7: cytokeratin 7; P-15: gross cystic disease fluid protein (GCDFP-15); MAG: mammaglobin; TP: true positives; TN: true negatives; FP: false positive; FN: false negative; S: sensitivity; Sp: specificity; PPV: positive predictive value; + LR: positive likelihood ratio; − LR: negative likelihood ratio.

ISSN: 1746-1596