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Table 1 Summary of the clinical and histological data of 18 patients with primary and recurrent gliomas

From: Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas

Case Age (y) Sex Site of tumor Interval of biopsies (m) Survival (m) Histology P/R Adjuvant therapy
1 20 M RTL 15 ALIVE PA2 R
    RTL    RA3 -
2 48 M LTL 24 ALIVE PA2 R
    LTL    RA3 -
3 55 M RFL 13 14 PA3 -
    RFL    RA3 -
4 50 F LTL 74 ALIVE PA2 R
    LTL    RA3 T
5 30 M RFL 662 ALIVE PA2 R
    RFL    RA3 -
6 41 F RTL 42 64 PA2 R
    RTL    RA3 -
7 50 M LOL 9 18 PA3 R
    LOL    RGB T
8 15 F LFL 31 49 PA3 R
    LFL    RGB CVP
9 27 F RFL 33 98 PA3 R
    RFL    RGB T
10 56 F RPL 12 32 PA3 R
    RPL    RGB -
11 69 F RFL 11 16 PGB R
    RFL    RGB -
12 44 M LPL 3 6 PGB R
    LPL    RGB -
13 47 M LFL 9 12 PGB -
    LFL    RGB T
14 55 M LTL 13 19 PGB R
    LTL    RGB T
15 62 M RFL 6 18 PGB R
    RFL    RGB T
16 54 M RTL 12 14 PGB R
    RTL    RGB T
17 41 M RTL 10 24 PGCGB R
    RTL    RGCGB T
18 17 F RTL 15 29 PGCGB R
    RTL    RGCGB CVP
  1. Abbreviations: Histology: P for primary and R for recurrence; A2, diffuse astrocytoma; A3, anaplastic astrocytoma; GB, glioblastoma; GCGB, giant cell glioblastoma; LFL, left frontal lobe; RFL, right frontal lobe; LTL, left temporal lobe; RTL, right temporal lobe; RPL, right parietal lobe; ROL, right occipital lobe; R, radiotherapy; CVP, Carbo/VP-16 chemotherapy; T, Temodal; female; M, male; y, year; m, month; Interval is the time in months between the two biopsies