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Table 2 Summary of methyaltion conditions and immunoreactivity of 18 patients with primary and recurrent gliomas

From: Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas

Cases

HT

DNMT

EGFR

MGMT

  

PGL

RGL

PGL

RGL

PGL

RGL

1

A2 → A3

2

A2 → A3

-

-

3

A3 → A3

-

-

4

A2 → A3

-

-

-

-

5

A2 → A3

+

-

-

6

A2 → A3

7

A3 → GB

-

-

-

-

-

-

8

A3 → GB

-

-

-

-

-

-

9

A3 → GB

-

-

-

10

A3 → GB

-

-

-

-

-

-

11

GB → GB

-

-

-

-

12

GB → GB

-

-

-

-

-

-

13

GB → GB

-

-

-

14

GB → GB

-

-

-

-

15

GB → GB

-

-

16

GB → GB

-

-

17

GCGB → GCGB

18

GCGB → GCGB

  1. Abbreviations: no mark, hypermethylation; oval mark, unmethylation; PGL, primary glioma; RGL, recurrent glioma;HT, histological tranformation; A2, diffuse astrocytoma; A3, anaplastic astrocytoma; GB, glioblastoma; GCGB, giant cell glioblastoma; + positive immunoreactivity; - negative immunoreactivity