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Table 1 Associations between MCM3 expression and clinicopathological factors

From: High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma

 

MCM3 expression

Factor

Low

High

P

n(%)

133 (59.4)

91 (40.6)

 

Age (continuous)

  

0.858

Mean

67.36

67.25

Median

69.00

69.00

Range

46-81

47-83

Location

  

0.893

Dorsal trunk

33 (26.0)

23 (25.6)

Frontal trunk

16 (12.6)

12 (13.3)

Arms

22 (17.3)

18 (20.0)

Legs

37 (29.1)

23 (25.6)

Head and neck

19 (15.0)

14 (15.6)

Unknown

6

1

Histological subtype

  

0.003

SSM

89 (66.9)

53 (58.9)

LMM

18 (13.5)

5 (5.6)

NMM

23 (17.3)

30 (33.3)

Other

3 (2.3)

2 (2.2)

Unknown

 

1

Breslow thickness

  

<0.001

Mean

1.48

1.94

Median

0.55

1.05

Range

0.08-40

0.15-14

Unknown

1

1

Breslow categories

  

<0.001

≤ 1 mm

93 (70.5)

44 (48.9)

1.1-2.0 mm

19 (14.4)

15 (16.7)

2.1-4.0 mm

14 (10.6)

23 (25.6)

> 4.0 mm

6 (4.5)

8 (8.9)

Unknown

1

1

Clark level

  

<0.001

II

58 (43.9)

19 (21.3)

III

58 (43.9)

39 (43.8)

IV-V

16 (12.1)

31 (34.8)

Unknown

1

2

Ulceration

  

<0.001

No

122 (91.7)

67 (74.4)

Yes

11 (8.3)

23 (25.6)

Unknown

 

1

Clinical stage

  

0.003

1

108 (91.5)

50 (75.8)

2-4

10 (8.6)

16 (24.2)

Unknown

15

24

Vascular invasion

  

0.016

No

129 (97.0)

81 (89.0)

Yes

4 (3.0)

10 (11.0)

Mitotic count

  

<0.001

0/mm2

87 (65.4)

27 (29.7)

> = 1/mm2

46 (34.6)

64 (70.3)

Lymphocytic infiltrate

  

0.463

None-mild

40 (30.5)

23 (25.6)

Moderate-brisk

93 (69.9)

67 (74.4)

Unknown

 

1

Ki67 expression

  

0.001

Low

100 (85.5)

58 (65.9)

High

17 (14.5)

30 (34.1)

Unknown

16

3

RBM3 expression

  

0.025

Low

46 (37.4)

48 (52.7)

High

77 (62.6)

43 (47.3)

Unknown

10

0

  1. P-values refer to Mann Whitney U test for comparison of medians and Chi square test for X × 2 tables. The categories marked as unknown were not included in the analysis.
  2. Low RBM3 expression corresponds to a nuclear staining intensity of negative to moderate and high expression corresponds to strong staining as previously described [12].