Table 1 Demographic and Clinic-pathological features of the subjects under study
Variable | CTR | COPD | LC |
|---|---|---|---|
(N = 33) | (N = 23) | (N = 26) | |
Age (y) | 55 (23–82) 2 | 66 (41–85)2 | 66 (25–87)2 |
Male (%) | 15 (45) | 10 (44) | 18 (69) |
Female (%) | 18 (54) | 13 (56) | 8 (31) |
Smoking history (%) | |||
Never smoker | 33 (100) | 0 (0) | 8 (31) |
Ex-smokers | 0 (0) | 7 (30) | 7 (27) |
Smokers | 0 (0) | 16 (70) | 11 (42) |
Smoking Frequency (%) | |||
< 35 cigarette pack | 0 | 18 (78) | 10 (56) |
≥ 35 cigarette pack | 0 | 5 (22) | 8 (44) |
COPD by Spirometry (%) | |||
GOLD 0 | - | 4 (17) | 7 (27) |
GOLD 1 | - | 5 (22) | 1 (4) |
GOLD 2 | - | 5 (22) | 12 (46) |
GOLD 3 | - | 8 (35) | 5 (19) |
GOLD 4 | 1 (4) | 1 (4) | |
Histology (%) | - | - | |
NSCLCs | - | - | 25 (96) |
-SCC | - | - | 6 (23) |
-AD | - | - | 6 (23) |
-LCLC | - | - | 13 (50) |
SCLC | 1 (100) | ||
Cytological analysis (%) | |||
Normal cells | 29 (88)3 | 5 (22) | 8 (31) |
Inflammatory cells | 4 (12) | 18 (78) | 3 (12) |
Atypia cellular4 | - | - | 6 (23) |
CIS (cancer cells)5 | - | - | 12 (46) |
Sputum DNA (ng/mL) | 2.75 (0.00-4.95)6 | 15.95 (8.25-20.35)7 | 20.35 (4.95-28.60) |