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Table 4 Sensitivity, specificity, and positive/negative predictive values of CDX2 expression and CK7-/CK20+ immunophenotype in differentiating colorectal adenocarcinomas from pancreatic and gastric adenocarcinomas.

From: The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody

  Sensitivity Specificity PPV NPV
CK7-/CK20+ 63.6% 96.7% 96.2% 67.2%
CDX2 > 5% 96.6% 54.9% 73.5% 92.6%
CDX2 > 50% 78.0% 84.6% 86.8% 74.8%
  1. PPV: Positive Predictive Value NPV: Negative Predictive Value