Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis

Table 2 Sensitivity and specificity of each immunohistochemistry marker or association

IHC ANALYSIS	Sensitivity (95% CI)	Q	P	Specificity (95% CI)	Q	P
CK-19[10, 14–33]	0.81 (0.79-0.83)	192.02	<0.00001	0.73 (0.70-0.75)	254.49	<0.00001
GAL-3[10, 14–17, 19, 21, 25–56]	0.82 (0.81-0.84)	341.95	<0.00001	0.81 (0.79-0.82)	512.70	<0.00001
HBME-1[10, 14–19, 21, 24–27, 29, 30, 41, 51, 57–61]	0.77 (0.76-0.79)	298.64	<0.00001	0.83 (0.82-0.85)	444.58	<0.00001
CK-19 + HBME-1[14, 17]	0.86 (0.77-0.92)	0.41	0.5245	0.97 (0.89-1.00)	7.46	0.0063
GAL-3 + CK-19[14, 17]	0.91 (0.83-0.96)	0.01	0.9383	0.91 (0.81-0.97)	5.31	0.0212
GAL-3 + HBME-1[14, 17, 46, 51]	0.75 (0.67-0.81)	57.91	<0.00001	0.89 (0.82-0.94)	7.46	0.0587
GAL-3 + HBME-1 + CK-19[14, 17, 29]	0.85 (0.78-0.90)	0.25	0.8826	0.97 (0.90-0.99)	7.33	0.0256

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