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Table 2 Sensitivity and specificity of each immunohistochemistry marker or association

From: Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis

IHC ANALYSIS Sensitivity (95% CI) Q P Specificity (95% CI) Q P
CK-19[10, 1433] 0.81 (0.79-0.83) 192.02 <0.00001 0.73 (0.70-0.75) 254.49 <0.00001
GAL-3[10, 1417, 19, 21, 2556] 0.82 (0.81-0.84) 341.95 <0.00001 0.81 (0.79-0.82) 512.70 <0.00001
HBME-1[10, 1419, 21, 2427, 29, 30, 41, 51, 5761] 0.77 (0.76-0.79) 298.64 <0.00001 0.83 (0.82-0.85) 444.58 <0.00001
CK-19 + HBME-1[14, 17] 0.86 (0.77-0.92) 0.41 0.5245 0.97 (0.89-1.00) 7.46 0.0063
GAL-3 + CK-19[14, 17] 0.91 (0.83-0.96) 0.01 0.9383 0.91 (0.81-0.97) 5.31 0.0212
GAL-3 + HBME-1[14, 17, 46, 51] 0.75 (0.67-0.81) 57.91 <0.00001 0.89 (0.82-0.94) 7.46 0.0587
GAL-3 + HBME-1 + CK-19[14, 17, 29] 0.85 (0.78-0.90) 0.25 0.8826 0.97 (0.90-0.99) 7.33 0.0256