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Table 3 Positive likelihood ratio (Positive LR) and negative likelihood ratio (Negative LR) of each immunohistochemistry marker and association

From: Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis

IHC ANALYSIS Positive LR (95% CI) Q P Negative LR (95% CI) Q P
CK-19[10, 1433] 2.87 (2.10-3.92) 262.28 <0.00001 0.25 (0.18-0.35) 131.17 <0.00001
GAL-3[10, 1417, 19, 21, 2556] 4.24 (3.08-5.82) 605.28 <0.00001 0.21 (0.15-0.30) 508.27 <0.00001
HBME-1[10, 1419, 21, 2427, 29, 30, 41, 51, 5761] 6.93 (4.42-10.88) 355.63 <0.00001 0.22 (0.16-0.30) 234.36 <0.00001
CK-19 + HBME-1[14, 17] 16.71 (0.38-742.57) 6.35 0.0118 0.16 (0.10-0.25) 0.11 0.7385
GAL-3 + CK-19[14, 17] 8.49 (1.04-69.17) 6.83 0.0089 0.10 (0.05-0.19) 0.15 0.6943
GAL-3 + HBME-1[14, 17, 46, 51] 4.92 (1.70-14.27) 13.48 0.0037 0.23 (0.03-1.70) 107.69 <0.00001
GAL-3 + HBME-1 + CK-19[14, 17, 29] 17.19 (3.36-87.96) 3.69 0.1577 0.17 (0.11-0.24) 0.10 0.9508