Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis

Table 3 Positive likelihood ratio (Positive LR) and negative likelihood ratio (Negative LR) of each immunohistochemistry marker and association

IHC ANALYSIS	Positive LR (95% CI)	Q	P	Negative LR (95% CI)	Q	P
CK-19[10, 14–33]	2.87 (2.10-3.92)	262.28	<0.00001	0.25 (0.18-0.35)	131.17	<0.00001
GAL-3[10, 14–17, 19, 21, 25–56]	4.24 (3.08-5.82)	605.28	<0.00001	0.21 (0.15-0.30)	508.27	<0.00001
HBME-1[10, 14–19, 21, 24–27, 29, 30, 41, 51, 57–61]	6.93 (4.42-10.88)	355.63	<0.00001	0.22 (0.16-0.30)	234.36	<0.00001
CK-19 + HBME-1[14, 17]	16.71 (0.38-742.57)	6.35	0.0118	0.16 (0.10-0.25)	0.11	0.7385
GAL-3 + CK-19[14, 17]	8.49 (1.04-69.17)	6.83	0.0089	0.10 (0.05-0.19)	0.15	0.6943
GAL-3 + HBME-1[14, 17, 46, 51]	4.92 (1.70-14.27)	13.48	0.0037	0.23 (0.03-1.70)	107.69	<0.00001
GAL-3 + HBME-1 + CK-19[14, 17, 29]	17.19 (3.36-87.96)	3.69	0.1577	0.17 (0.11-0.24)	0.10	0.9508

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