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Table 3 Cox proportional hazards model for colorectal cancer specific survival related to MSI screening status and beta-catenin overexpression in the full cohort and in stage III-IV disease

From: Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer

  Full cohort Stage III-IV disease
  HR(95% CI) p-value N(events) HR(95% CI) p-value n(events)
   Univariable    Univariable  
MSS 1,00 0,010** 438(157) 1,00 0,036* 201(122)
MSI 0,50(0,29-0,84)   77(15) 0,46(0,23-0,95)   23(8)
   Multivariable    Multivariable  
MSS 1,00 0,010* 389(137) 1,00 0,011* 185(107)
MSI 0,46(0,25-0,84)   73(13) 0,33(0,14-0,78)   20(6)
   Univariable    Univariable  
Bata-catenin low 1,00 0,056 251(96) 1,00 0,063 112(72)
Bata-catenin High 0,75(0,56-1,01)   276(86) 0,73(0,52-1,02)   122(66)
   Multivariable    Multivariable  
Bata-catenin low 1,00 0,031* 223(80) 1,00 0,036* 98(60)
Bata-catenin High 0,70(0,51-0,97)   247(75) 0,67(0,46-0,97)   113(57)
  1. *Significant at the 0.05 level. **Significant at the 0.01 level. P-value from multivariable analysis adjusted for age (>/<=75 years), gender, T-stage (I-II, III, IV), N-stage (0,1,2), M-stage (0, 1), differentiation grade (high-intermediate vs low) and vascular invasion (+/−/unknown). Beta-catenin low = beta-catenin score 0–2. Beta catenin high = beta-catenin score 3–5.