Table 3 Associations of KRAS mutation status with clinicopathological and molecular characteristics in 153 patients
n (%) | KRAS wild type | KRAS mutated | P-value |
|---|---|---|---|
136(89%) | 17(11%) | ||
Age | |||
Mean | 63.38 | 60.71 | 0.293 |
Median | 62.00 | 62.00 | |
Range | 47-83 | 49-69 | |
Histological subtype | |||
Mucinous | 5(3.7) | 7(41.2) | <0.001 |
Serous | 87(64.0) | 3(17.6) | |
Endometroid | 30(22.1) | 5(29.4) | |
Other | 14(10.3) | 2(11.8) | |
Differentiation grade | |||
Well-moderate | 36(26.5%) | 11(64.7) | 0.001 |
Poor | 100(73.5) | 6(35.3) | |
Clinical Stage | |||
I | 20(16.0) | 6(40.0) | 0.088 |
II | 16(12.8) | 2(13.3) | |
III | 70(56.0) | 4(26.7) | |
IV | 19(15.2) | 3(20.0) | |
Missing | 11 | 15 | |
ER | |||
≤10% | 56/43.1) | 11(64.7) | 0.092 |
>10% | 74(56.9) | 6(35.3) | |
Missing | 6 | 0 | |
PR | |||
≤10% | 111(84.1) | 10(62.5) | 0.035 |
>10% | 21(15.9) | 6(37.5) | |
Missing | 4 | 1 | |
AR | |||
≤10% | 112(82.4) | 13(76.5) | 0.554 |
>10% | 24(17.6) | 4(23.5) | |
Missing | 0 | 0 | |
Chek1 | |||
Low | 36(28.8) | 8(53.3) | 0.053 |
High | 89(71.2) | 7(46.7) | |
Missing | 11 | 2 | |
Chek2 | |||
Low | 43(33.6) | 9(56.2) | 0.075 |
High | 85(66.4) | 7(43.8) | |
Missing | 8 | 1 |