Table 2 Relationship between advanced gastric cancer pathology TIMP3 methylation and its protein expression level
From: Promoter methylation and expression of TIMP3 gene in gastric cancer
Index | n | TIMP3 promoter methylation | TIMP3 protein tumor size | |
|---|---|---|---|---|
Tumor size (cm) | <5 | 5 | 3 (60.0) | 1 (20.0) |
5 − 10 | 45 | 42 (93.3) | 18 (40.0) | |
>10 | 8 | 7 (87.5) | 2 (25.0) | |
General types | Borr.2 | 12 | 10 (83.3) | 4 (33.3) |
Borr.3 | 37 | 33 (89.2) | 15 (40.5) | |
Borr.4 | 9 | 9 (100.0) | 2 (22.2) | |
Histological differentiation | Differentiated | 44 | 39 (88.6) | 17 (38.6) |
Undifferentiated | 14 | 13 (92.9) | 4 (28.6) | |
Growth pattern | Clumps + nested | 27 | 21 (77.8) | 15 (55.6) |
Diffuse-like | 31 | 31 (100.0) b | 6 (19.4) b | |
Lymph node metastasis | <7 | 36 | 30 (83.3) | 17 (47.2) |
≥7 | 22 | 22 (100.0) a | 4 (18.2) a | |
Infiltration | Submucosal muscularis | 6 | 3 (50.0) | 1 (16.7) |
Subserosal | 23 | 21 (91.3) a | 9 (39.1) | |
Serosa | 29 | 28 (96.6) | 11 (37.9) |