Usefulness and limitations of E-cadherin and β-catenin in the classification of breast carcinomas in situ with mixed pattern

Table 1 Morphology and immunophenotype of 25 breast carcinomas in situ with mixed pattern analyzed from breast biopsies

	Morphological pattern of *in situ* lesion			Morphology of *in situ* lesion with mixed pattern			E-cadherin immunophenotype		β-catenin immunophenotype
Case #	Lobular	Ductal	Mixed	Nuclear pleomorphism	Comedonecrosis	Mixed cytology or architecture	Lobular areas	Ductal areas	Lobular areas	Ductal areas
1	Yes	Yes	Yes	No	No	Yes	-	+	-	+
2	No	No	Yes	No	No	Yes	-	+	-	+
3	No	No	Yes	No	No	Yes	+	+	+	+
4	No	No	Yes	No	No	Yes	+	+	+	+
5	No	No	Yes	Yes	No	No	-	+	-	+
6	No	No	Yes	No	No	Yes	+	+	+	+
7	Yes	No	Yes	No	No	Yes	+	+	+	+
8	No	No	Yes	No	No	Yes	+	+	+	+
9	No	No	Yes	Yes	Yes	No	-	+	-	+
10	No	No	Yes	No	No	Yes	-	+	-	+
11	No	Yes	Yes	No	No	Yes	+	+	+	+
12	No	No	Yes	No	No	Yes	+	+	NA	NA
13	No	No	Yes	Yes	Yes	No	-	-	-	-
14	Yes	Yes	Yes	No	No	Yes	-	+	-	+
15	No	Yes	Yes	No	No	Yes	+	+	+	+
16	No	No	Yes	Yes	No	Yes	-	+	NA	NA
17	Yes	No	No	Yes	No	Yes	-	+	-	+
18	Yes	Yes	Yes	No	No	Yes	-	+	NA	NA
19	No	Yes	Yes	No	No	Yes	+	+	+	+
20	No	No	Yes	No	No	Yes	+	+	+	+
21	No	No	Yes	No	No	Yes	-	+	-	+
22	Yes	Yes	Yes	No	No	Yes	-	+	NA	NA
23	No	No	Yes	No	No	Yes	-	+	-	+
24	No	No	Yes	Yes	No	No	-	+	NA	NA
25	No	Yes	Yes	No	No	Yes	+	+	+	+

ISSN: 1746-1596