Tumors | Clinical features | Histopathology | Immunohistochemistry | |
---|---|---|---|---|
Positive | Negative | |||
CDC | A male to female ratio of approximately 2:1 with a mean age of occurrence in the sixth decade | Angulated tubules or tubulopapillary and glandular structures associated with a desmoplastic stroma; Large irregular tumor cells with abundant eosinophilic or clear cytoplasm and large hyperchromatic nuclei with prominent eosinophilic nucleoli | CK(AE1/AE3) Vimentin E-cadherin CK7 CD10(weakly) | CK20 |
CCRCC | Occurs in adults (average 70 years), often associated with VHL disease. The tumor are typically multi-focal and bilateral | Solid, alveolar and acinar patterns, containing a network of small thin-walled blood vessels. The tumor cells have abundant clear cytoplasm with round and uniform nuclei | CD10 CK Vimentin | E-cadherin CK7 CK20 |
Renal medullary carcinoma | A rare tumor. Occurs in younger cohort mainly in the third decade of life, all the patients had sickle cell trait and hemoglobin abnormalities | Poorly differentiated tumor cells arrange as sheets and reticular pattern. The cells are eosinophilic with clear nuclei and prominent nucleoli, often mixed with neutrophils and lymphocyte at the margin | CK EMA CEA | Vimentin |
Urothelial carcinoma with glandular differentiation or Urothelial adenocarcinoma | Less common type of urothelial carcinoma. A tumor with mixed glandular and urothelial differentiation is definited | True glandular spaces present, tubular or enteric glands with mucin secretion. Tumor cells have moderate to abundant cytoplasm and large hyperchromatic nuclei | CK CK7 CK20 (in most adenocarcinoma) | Vimentin CD10 |
NET | Rare renal tumor. Occurs in adults (average 60 years), with no sex predilection | Trabecular nests or solid nests. Largely polygonal tumor cells with granular clear cytoplasm and round to oval uniform nuclei with rare mitotic figures | CK CgA Syn NSE (weakly) | Vimentin Desmin |
Epithelioid AML | More than a half have a history of tuberous sclerosis; both sexes are equally affected, the mean age is 38 years | Round to polygonal tumor cells arranged in sheets, with abundant granular cytoplasm and enlarged vasicular nuclei often with prominent nucleoli | Melan-A HMB-45 Actin (partly) | CK CK7 E-cadherin |
Pigmented paraganglioma | Rare renal tumor. Most tumor are small, occurs in adults | Tumor cells arranged in nests (Zellballen), delicate fibrovascular stroma, large round or polygonal tumor cells with round or oval nuclei | CD56 CgA Syn S-100 (sustentacular cells positive) | CK CK8/18 Vimentin CD10 Actin |
Mesenchymal chondrosarcoma of kidney | Very rare renal tumor | Undifferentiated spindle to oval shaped cells, and islands of cartilage | S-100 CD99 Vimentin | CK EMA E-cadherin |