CyclinD1, a prominent prognostic marker for endometrial diseases

Diagnostic Pathology

Table 1 Expression of CyclinD1 in the tissue of endometrial lesions

Pathological type	Cases assessed	CyclinD1
Pathological type	Cases assessed	+	-	Positive Rate%*
Simple hyperplasia	27	8	19	30%
Atypical complex hyperplasia	41	20	21	49%
Endometrioid carcinoma	103	54	49	52%
Endometrial serous carcinoma	21	8	13	38%
Clear cell carcinoma	9	6	3	67%

*: Grade and score by the intensity of immunoreactivity staining: 0 point for absent, 1 point for weak, 2 points for moderate and 3 points for strong; then grade by the extent of tissue staining: 0 point for no positive staining cells, 1 point for positive ratio <25%, 2 points for 25%-49%, 3 points for 50%-79% and 4 points for ≥ 80%. Finally, multiply the two score systems: ≤3 points for negative, >3 points for positive.

ISSN: 1746-1596