Table 2 Main results of pooled odds ratios (ORs) with confidence interval (CI) in the meta-analysis
Variables | No. of studies | Ser/Ser vs Cys/Cys | Ser/Ser vs Ser/Cys | Ser/Cys vs Cys/Cys | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | Ph | P | OR (95% CI) | Ph | P | OR (95% CI) | Ph | P | ||
Total | 30 | 0.885(0.765 1.024) | 0.002 | 0.101 | 0.982(0.898 1.075) | 0.023 | 0.698 | 0.909(0.802 1.029) | 0.006 | 0.131 |
Ethnicity | ||||||||||
Asian | 17 | 0.850(0.732 0.986) | 0.064 | 0.032 | 0.973(0.860 1.100) | 0.102 | 0.659 | 0.887(0.771 1.020) | 0.012 | 0.092 |
Caucasian | 13 | 0.946(0.683 1.310) | 0.005 | 0.738 | 0.993(0.866 1.138) | 0.041 | 0.915 | 0.970(0.734 1.281) | 0.070 | 0.829 |
Source of controls | ||||||||||
PB | 14 | 0.993(0.810 1.216) | 0.069 | 0.945 | 0.974(0.877 1.083) | 0.377 | 0.630 | 0.956(0.833 1.098) | 0.367 | 0.527 |
HB | 16 | 0.798(0.649 0.982) | 0.007 | 0.033 | 0.991(0.858 1.144) | 0.007 | 0.900 | 0.837(0.689 1.017) | 0.001 | 0.073 |
Variables | No. of studies | Ser/Ser + Ser/Cys vs Cys/Cys (dominant) | Ser/Ser vs Ser/Cys + Cys/Cys (recessive) | Ser allele vs Cys allele | ||||||
OR (95% CI) | P h | P | OR (95% CI) | P h | P | OR (95% CI) | P h | P | ||
Total | 30 | 0.133(0.111 0.161) | 0.000 | 0.000 | 0.543(0.399 0.739) | 0.000 | 0.000 | 0.947(0.880 1.019) | 0.000 | 0.143 |
Ethnicity | ||||||||||
Asian | 17 | 0.160(0.137 0.187) | 0.001 | 0.000 | 0.875(0.684 1.118) | 0.000 | 0.285 | 0.931(0.865 1.000) | 0.064 | 0.052 |
Caucasian | 13 | 0.101(0.069 0.147) | 0.000 | 0.000 | 0.300(0.198 0.454) | 0.000 | 0.000 | 0.970(0.836 1.125) | 0.000 | 0.686 |
Source of controls | ||||||||||
PB | 14 | 0.143(0.111 0.184) | 0.000 | 0.000 | 0.429(0.261 0.705) | 0.000 | 0.001 | 0.979(0.897 1.069) | 0.087 | 0.644 |
HB | 16 | 0.122(0.091 0.163) | 0.000 | 0.000 | 0.670(0.455 0.986) | 0.000 | 0.042 | 0.916(0.817 1.026) | 0.000 | 0.131 |