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Table 4 Univariate and multivariate analyses of recurrence and survival (Cox regression)

From: Expression of CD44v6 and integrin-β1 for the prognosis evaluation of pancreatic cancer patients after cryosurgery

Variables

Disease-free survival

Overall survival

HR (95% CI)

P value

HR (95% CI)

P value

Univariate analysis

    

Sex (Male/Female)

1.5 (0.7–3.5)

0.236

1.7 (0.9–3.5)

0.178

Age (≤60/>60)

0.8 (0.4–2.6)

0.421

1.4 (0.9–3.6)

0.279

Histological diagnosis (Head and Body PC/Tail PC)

1.8 (0.9–3.9)

0.145

1.5 (0.6–3.4)

0.243

Clinical stages (I+II/III+IV)

2.8 (1.4–5.9)

0.018

3.2 (0.9–6.7)

<0.01

Tumor differentiation (Poor and Moderate/High)

1.2 (0.3–3.7)

0.231

1.8 (0.5–4.4)

0.137

Tumor size (≤4 cm/>4 cm )

1.8 (0.8–4.1)

0.165

2.2 (1.2–4.2)

0.089

LNM (Negative/Positive)

3.9 (1.1–8.6)

<0.01

4.5 (1.5–8.7)

<0.01

Liver metastasis (Negative/Positive)

3.5 (1.5–6.4)

<0.01

4.1 (1.6–8.5)

<0.01

CA199(U/ml) (≤1000/ >1000)

2.4 (0.7–4.3)

0.059

2.0 (0.6–4.8)

0.107

KPS (≤80/>80)

1.9 (0.5–4.8)

0.156

2.3 (0.8–4.7)

0.119

CD44v6 mRNA (Low/High)

3.1 (1.2–6.4)

0.017

2.9 (1.4–6.8)

0.033

Integrin-β1 mRNA (Low/High)

2.7 (1.3–6.3)

0.034

3.2 (1.5–6.8)

0.025

CD44v6 protein (Low/High)

3.2 (1.1–7.1)

0.012

3.9 (1.2–7.5)

<0.01

integrin-β1 protein (Low/High)

2.7 (0.8–6.7)

0.045

3.0 (1.1–6.2)

0.013

Multivariate analysis

    

Clinical stages (I+II/III+IV)

3.5 (0.9–7.5)

<0.01

3.6 (1.1–7.1)

<0.01

LNM (Negative/Positive)

2.8 (0.6–7.2)

0.033

3.2 (1.0–6.9)

0.021

Liver metastasis(Negative/Positive)

3.3 (0.7–6.8)

0.015

3.5 (1.2–7.5)

<0.01

CD44v6 mRNA (Low/High)

2.9 (1.2–6.5)

0.028

2.9 (1.4–6.8)

0.033

Integrin-β1 mRNA (Low/High)

2.4 (0.6–6.7)

0.096

3.2 (1.1–7.2)

0.019

CD44v6 protein (Low/High)

3.3 (1.3–7.8)

0.010

3.7 (1.3–7.5)

<0.01

Integrin-β1 protein (Low/High)

2.5 (0.7–6.8)

0.067

3.2 (1.2–6.7)

0.016