Figure 2

Histopathological findings of inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement. (A) and (B) The neoplastic cells were loosely arrayed and distributed in an abundant myxoid stroma. There were striking neutrophilic inflammatory infiltrates in the lesion, while lymphoplasma cells were only occasionally observed (inserted panel) (A and B, hematoxylin and eosin [H&E] staining, 200× original magnification; inserted panel, H&E staining, 400× original magnification). (C) The tumor cells showed ganglion-like morphology, characterized by an abundant and slightly amphophilic cytoplasm, round nuclei, vesicular chromatin, and large nucleoli (H&E staining, 400× original magnification). (D) A few binucleate cells were found in the tumor (H&E staining, 400× original magnification). (E) In focal area, the tumor cells were tightly packed around dilated vessels (H&E staining, 100× original magnification). (F) The tumor infiltrated the adjacent intestinal wall in a vague nodular pattern (H&E staining, 40× original magnification).