Figure 3From: Inflammatory myofibroblastic tumor with RANBP2 and ALKgene rearrangement: a report of two cases and literature reviewImmunohistochemistry features of inflammatory myofibroblastic tumor. The tumor cells showed nuclear membranous ALK immunostaining (A), cytomembranous CD30 immunostaining (B), and cytoplasmic desmin immunostaining (C) (A and B, 400× original magnification; C, 200× original magnification). (D) Interphase fluorescence in situ hybridization (FISH) revealed 1 fused signal (arrow) in the tumor nucleus, indicating the presence of RANBP2-ALK translocation. One separate orange signal and 1 separate green signal indicated a normal ALK and a normal RANBP2 locus, respectively (1000× original magnification).Back to article page