Table 2 Genetic and immunohistochemical characteristics of 11 cases of inflammatory myofibroblastic tumor with RANBP2-ALK gene fusion
Case | Genetic features | Immunohistochemical features | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
RANBP2toALKfusion point | Detection techniques | ALK | Desmin | SMA | Caldesmin | CD30 | CK | EMA | S100 | |
1 | Exon 18 to exon 20 | RT-PCR, FISH | NM+ | / | / | / | / | / | / | / |
2 | Exon 18 to exon 20 | RT-PCR, FISH | NM+ | / | / | / | / | / | / | / |
3 | Exon 19 to exon 20* | RT-PCR, FISH | CP+ | + | + | - | / | + | / | - |
4 | Exon 18 to exon 20 | RT-PCR | NM+ | - | - | / | - | - | / | - |
5 | Exon 18 to exon 20 | RT-PCR | NM+ | + | - | / | / | - | / | / |
6 | Exon 18 to exon 20 | RT-PCR | NM+ | + | - | - | + | - | - | - |
7 | Exon 18 to exon 20 | RT-PCR | NM+ | + | / | - | + | / | / | - |
8 | Exon 18 to exon 20 | RT-PCR | NM+ | + | + | - | + | - | / | - |
9 | Unknown | FISH | CP+ | + | - | / | - | + | / | - |
10 | Unknown | FISH | NM+ | + | + | - | + | - | - | - |
11 | Exon 18 to exon 20 | RT-PCR, FISH | NM+ | + | + | - | + | - | - | - |
Total | / | / | 100% (11/11) | 89% (8/9) | 50% (4/8) | 0% (0/6) | 71% (5/7) | 25% (2/8) | 0% (0/3) | 0% (0/8) |