Inducible nitric oxide synthase expression in gastric adenocarcinoma: impact on lymphangiogenesis and lymphatic metastasis

Table 4 Results of statistical analyses between immunohistochemical and clinicopathologic parameters in cases with gastric carcinoma

Variables	iNOS score			D2-40
Variables	iNOS-T	iNOS-S	iNOS-E	LID	P-LVD	I-LVD
Age*
r value	0.007	0.008	0.07	0.06	0.05	0.01
p Value	0.92	0.96	0.86	0.71	0.99	0.85
Gender ( male or female)**
p Value	0.67	0.93	0.34	0.84	0.20	0.15
Location of tumor (proximal or distal) **
p Value	0.53	0.17	0.005	0.95	0.77	0.60
Tumor size (cm)*
r value	0.31	0.06	0.06	0.29	0.53	0.37
p Value	0.05	0.70	0.70	0.07	< 0.001	0.01
Histological type ( NOS/tubular/papillary or mucinous/poorly cohesive) **
p Value	0.46	0.54	0.51	0.14	0.44	0.62
Differentiation ( Well/moderate or poorly/signet ring cell) **
p Value	0.01	0.748	0.92	0.001	0.001	0.03
Inflammatory response (score 1 + 2 or score 3) **
p value	0.01	0.89	0.51	0.02	0.001	0.01
LVI [H& E](positive or negative) **
p Value	0.002	0.03	0.01	0.001	0.001	< 0.001
LI [D2-40](positive or negative) **
p Value	0.002	0.02	0.01	< 0.001	0.001	< 0.001
nLI*
r value	0.64	0.37	0.44	0.98	0.65	0.63
p Value	< 0.001	0.017	0.004	< 0.001	< 0.001	< 0.001
nNm*
r value	0.61	0.30	0.40	0.83	0.86	0.78
p Value	< 0.001	0.05	0.009	< 0.001	< 0.001	< 0.001
pN (N0 or N1/2/3) **
p Value	0.001	0.003	0.023	< 0.001	< 0.001	< 0.001
pT (T1 + 2 orT3 + 4) **
p Value	0.05	0.70	0.70	0.07	< 0.001	0.01
TNM stage (I + II or III + IV) **
p Value	0.0002	0.067	0.02	< 0.001	< 0.001	< 0.001

* Pearson’s correlation analysis/Spearman’s correlation analysis and **Independent sample t test/the Mann–Whitney U tests were used.

ISSN: 1746-1596