Diagnostic Pathology

Table 4 BCL2 protein expression and t(14;18) translocation in the FL subgroups

From: Immunophenotypic features and t(14;18) (q32;q21) translocation of Chinese follicular lymphomas helps to distinguish subgroups

FL grading	BCL2 positive		t(14;18) translocation positive
	n/N (%)	P(R)	n/N (%)	P(R)
FL1	38/40 (95.0)	1.000^#	22/32 (68.8)	0.498^#
FL2	19/19 (100)	1.000^#	14/17 (82.4)	0.498^#
FL3A	25/30 (83.3)	1.000^#	14/27 (51.9)	0.005 ^*
FL3B	19/22 (86.4)	1.000^#	2/18 (11.1)	0.005 ^*
FL1-2	57/59 (96.6)	0.043 ^#	36/49 (73.5)	< 0.001 ^*
FL3	44/52 (84.6)	0.043 ^#	16/45 (35.6)	< 0.001 ^*
FL1-2	57/59 (96.6)	0.114^*	36/49 (73.5)	0.057^*
FL3A	25/30 (83.3)	0.114^*	14/27 (51.9)	0.057^*
FL1-3A	82/89 (92.1)	0.412^#	50/76 (65.8)	< 0.001 ^*
FL3B	19/22 (86.4)	0.412^#	2/18 (11.1)	< 0.001 ^*
Total	101/111 (91.0)		52/94 (55.3)

^*Pearson’s Chi-square test. ^#Fisher’s exact test. Bold text indicates significant P value. n/N (%), number positive/total number tested (percentage). FL, follicular lymphomas; FL1, FL grade 1; FL2, FL grade 2; FL3A, FL grade 3A; FL3B, FL grade 3B.

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ISSN: 1746-1596

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