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Table 3 Copy number variations of mtDNA in gastric cancer — univariate associations with clinicopathological characteristics

From: Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients

Characteristics

     Copy number <3.61

 

     Copy number >5.35

 

OR*(95% CI)

P

OR*(95% CI)

P

Male vs. Female

1.55 (0.42-5.70)

0.51

1.75 (0.37-8.30)

0.48

Age1

1.00 (0.65-1.52)

0.98

1.10 (0.67-1.79)

0.71

Tumor localization2

1.11 (0.51-2.42)

0.80

1.22 (0.50-2.99)

0.66

Tumor size3

1.31 (0.66-2.60)

0.45

1.37 (0.63-3.01)

0.43

Differentiation4

1.78 (0.58-5.49)

0.32

1.11 (0.31-4.04)

0.87

Tumor invasion5

0.82 (0.46-1.47)

0.50

0.69 (0.36-1.34)

0.27

TNM stage6

0.84 (0.40-1.78)

0.65

0.86 (0.36-2.03)

0.73

Lymph node metastasis

4.93 (1.28-19.04)

0.02

4.00 (0.91-17.58)

0.07

Survival status7

1.20 (0.39-3.73)

0.75

1.81 (0.50-6.50)

0.37

  1. *OR: odds ratio with 95% confidence interval; 1Age (per 10 years); 2Tumor localization (gastric cardia; gastric body; gastric antrum); 3Tumor size (≤3 cm; >3 cm and ≤5 cm; >5 cm); 4Differentiation (well or moderate; poor or undifferentiation); 5Tumor invasion (T1; T2; T3; T4); 6TNM stage (I; II; III; IV); 7Survival status (Alive vs. Dead). The cases with 3.61-5.35 mtDNA copies were used as reference.