Table 7 Prognostic value of clinicopathological factors and copy number variation of mtDNA in univariate and multivariate Cox regression analysis (n=103)
| Â | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
Variable | Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P |
Copy number | Â | Â | Â | Â |
3.61~5.35 | 1.00 (reference) | Â | 1.00 (reference) | Â |
<3.61 | 1.51 (0.44-2.57) | 0.90 | 0.52 (0.20-1.38) | 0.19 |
>5.35 | 1.53 (0.58-4.02) | 0.39 | 1.07 (0.37-3.07) | 0.90 |
The number of lymph node metastasis | Â | Â | Â | Â |
0 | 1.00 (reference) | Â | 1.00 (reference) | Â |
1~6 | 6.86 (3.18-14.91) | <0.001 | 7.28 (2.87-18.49) | <0.001 |
7~15 | 6.41 (2.70-15.25) | <0.001 | 4.68 (1.65-13.28) | 0.004 |
≥16 | 16.75 (5.05-55.56) | <0.001 | 13.21 (3.33-52.45) | <0.001 |
Tumor invasion | Â | Â | Â | Â |
T1 | 1.00 (reference) | Â | 1.00 (reference) | Â |
T2 | 0.85 (0.16-4.67) | 0.86 | 0.63 (0.11-3.54) | 0.60 |
T3 | 4.36 (1.53-12.42) | 0.006 | 1.51 (0.46-4.92) | 0.49 |
T4 | 2.66 (1.30-5.48) | 0.001 | 3.33 (0.92-12.14) | 0.07 |
Differentiation | Â | Â | Â | Â |
Well/moderate | 1.00 (reference) | Â | 1.00 (reference) | Â |
Poor/undifferentiation | 2.22 (1.19-4.19) | 0.01 | 1.82 (0.86-3.82) | 0.12 |