Table 1 Correlation of SOX9 expression with clinicopathological features of osteosarcoma
Clinicopathological features | No.of cases | SOX9 expression | P | |
|---|---|---|---|---|
High(n, %) | Low(n, %) | |||
Age | ||||
<55 | 72 | 50 (69.4) | 22 (30.6) | NS |
≥55 | 94 | 70 (74.5) | 24 (25.5) | |
Gender | ||||
Male | 96 | 70 (72.9) | 26 (27.1) | NS |
Female | 70 | 50 (71.4) | 20 (28.6) | |
Tumor size (cm) | ||||
>8 | 88 | 62 (70.5) | 26 (29.5) | NS |
≤8 | 78 | 58 (74.4) | 20 (25.6) | |
Anatomic location | ||||
Tibia/femur | 103 | 76 (73.8) | 27 (26.2) | NS |
Elsewhere | 63 | 44 (69.8) | 19 (30.2) | |
Serum level of lactate dehydrogenase | ||||
Elevated | 90 | 70 (77.8) | 20 (22.2) | NS |
Normal | 76 | 50 (65.8) | 26 (34.2) | |
Serum level of alkaline phosphatase | ||||
Elevated | 108 | 80 (74.1) | 28 (25.9) | NS |
Normal | 58 | 40 (69.1) | 18 (30.9) | |
Clinical stage | ||||
IIA | 68 | 32 (47.1) | 36 (52.9) | 0.02 |
IIB/III | 98 | 88 (89.8) | 10 (10.2) | |
Distant metastasis | ||||
Absent | 124 | 78 (62.9) | 46 (37.1) | 0.008 |
Present | 42 | 42 (100.0) | 0 (0) | |
Response to chemotherapy | ||||
Good | 68 | 32 (47.1) | 36 (52.9) | 0.02 |
Poor | 98 | 88 (89.8) | 10 (10.2) | |