Skip to main content


Figure 2 | Diagnostic Pathology

Figure 2

From: Overexpression of regenerating gene Iα appears to reflect aberration of crypt cell compartmentalization in sessile serrated adenoma/polyps of the colon

Figure 2

Histology and immunohistochemistry for REG Iα and Ki67 of SSA/P and HP. (A) SSA/P showing irregularly branching crypts, horizontally arranged basal crypts, and crypt dilatation (hematoxylin & eosin); (B) REG Iα is mainly expressed in goblet cells in the entire crypt and surface epithelium in SSA/P (immunoperoxidase); (C) Ki67-immunoreactive cells in SSA/P are either increased or decreased or both, with irregular distribution; (D) HP represents narrow-shaped crypts without luminal serration in the basal part (hematoxylin & eosin); (E) REG Iα is weakly and sparsely expressed in goblet cells in HP (immunoperoxidase); (F) Ki67-immunoreactive cells are distributed regularly in the basal part of crypts in HP.

Back to article page