Skip to main content

Table 1 Clinicopathological features of Langerhans cell sarcoma with only cutaneous involvement described in present and previous reports

From: Unusual cutaneous Langerhans cell sarcoma without extracutaneous involvement

No.

Authors (yr.)

Diagnosis

Age (year)/Gender

Clinical presentation

Immunophenotype

EM/MA

Treatment

Outcome

1

Pileri SA (2002) [5]

Langerhans cell sarcoma

50/Female

Multiple nodular lesions on skin

CD1a+/S-100+/CD68+/lysozyme+/CD20-/CD21-/CD45-/CD3-/CD30-/MPO-/EMA-

EBERs-

NA

NA

2

Pileri SA (2002) [5]

Langerhans cell sarcoma

10/Female

Single nodular lesion on skin

CD1a+/S-100+/CD68+/CD20-/CD21-/CD45-/CD3-/CD30-/CD34-/MPO-/EMA-

EBERs-

Surgery and radiotherapy

Alive in complete remission

3

Misery L (2003) [6]

Malignant Langerhans cell tumor

38/Female

Single red, hardened nodular lesion on skin

CD1a+/S-100+/CD68+/HAM56+/lysozyme+/CD45-/HMB45-/EMA-/CK-/CD20-/CD79-

Birbeck granules+

Surgery with large excision

2-year follow-up, no relapse/alive

4

The present case

Langerhans cell sarcoma

48/male

Ulcerated and nodular lesion on skin

CD1a+/S-100+/langerin+/CD68(focal)+/CD56-/CD3-/CD20-/CD21-/MPO-/CK-

EBERs-

Surgery and chemotherapy with CHOP regimen

PR, 1-year follow-up, no relapse/alive

  1. EM, electron microscopy; MA, molecular analysis; EMA, epithelial membrane antigen; CK, cytokeratin; MPO, myeloperoxidase; EBERs, Epstein-Barr virus-encoded small RNAs; PR, partial remission; NA, not available.