Table 2 Expression of CLAUDIN-10, CLAUDIN-14, CLAUDIN-17 and clinic pathological characteristics in gastric cancer patients
Item | n | CLAUDIN-10(+) | CLAUDIN-10(-) | P | n | CLAUDIN-14(+) | CLAUDIN-14(-) | P | n | CLAUDIN-17(+) | CLAUDIN-17(-) | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gastric cancer tissue | 50 | 12 | 38 | <0.01 | 50 | 29 | 21 | <0.01 | 50 | 9 | 41 | <0.01 |
Adjacent tissue | 50 | 36 | 14 | 50 | 12 | 38 | 50 | 35 | 15 | |||
Gender | ||||||||||||
Male | 34 | 8 | 28 | 0.664* | 34 | 20 | 14 | 0.355* | 34 | 7 | 27 | 0.475* |
Female | 16 | 4 | 12 | 16 | 9 | 7 | 16 | 2 | 14 | |||
Age(year) | ||||||||||||
≤60 | 26 | 7 | 19 | 1.000* | 26 | 15 | 11 | 1.000* | 26 | 4 | 22 | 0.677* |
>60 | 24 | 5 | 19 | 24 | 14 | 10 | 24 | 5 | 19 | |||
Histological grade | ||||||||||||
Well –differentiated | 14 | 4 | 10 | 1.000* | 14 | 6 | 8 | 0.641* | 14 | 3 | 11 | 1.000* |
Moderately differentiated | 25 | 7 | 18 | 25 | 15 | 10 | 25 | 5 | 20 | |||
Poor differentiated | 11 | 1 | 10 | 11 | 8 | 3 | 11 | 1 | 10 | |||
Lymph node metastasis | ||||||||||||
+ | 24 | 3 | 21 | <0.01 | 24 | 18 | 6 | <0.05 | 24 | 2 | 22 | <0.05 |
- | 26 | 9 | 17 | 26 | 11 | 15 | 26 | 7 | 19 | |||
E-cadherin | ||||||||||||
+ | 16 | 9 | 7 | <0.0 | 7 | 9 | 16 | 6 | 10 | <0.01 | ||
- | 3 | 1 | 16 | 22 | 12 | <0.05 | 34 | 3 | 31 | |||
Ki67 | 31 | |||||||||||
+ | 5 | 34 | 9 | 8 | 17 | 4 | 13 | 0.633* | ||||
- | 34 | 7 | 12 | 0.464* | 13 | 5 | 28 | |||||
26 | 1.000* | |||||||||||
17 | 17 | |||||||||||
33 | 33 | 20 | 33 |