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Table 2 Immunohistochemical staining results of p53, MAPK, topoIIα and Ki67 expression in OSCs

From: P53, MAPK, topoisomerase II alpha and Ki67 immunohistochemical expression and KRAS/BRAF mutation in ovarian serous carcinomas

 

Low-grade

High-grade

P

(n = 11)

(n = 70)

p53, n (%)

   

negative

11 (100)

10 (14.3)

< 0.001

positive

0 (0)

60 (85.7)

 

MAPK, n (%)

   

negative

4 (36.4)

58 (82.9)

0.003

positive

7 (63.6)

12 (17.1)

 

topoII alpha, n (%)

   

negative

7 (63.6)

13 (18.6)

0.001

positive

4 (36.4)

57 (81.4)

 

Ki67, median (min-max)

19 (7–54)

56.5 (18–98)

< 0.001*

  1. Based on χ2 test.
  2. *Based on Mann–Whitney U test.