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Table 1 Literature review of sensitivity and specificity of mutation-specific immunohistochemistry

From: Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies

Reference N L858R E746_A750del
   Sensitivity Specificity Sensitivity Specificity
Simonetti et al.[8] 78 100% 100% 63% 100%
Kato Y et al.[9] 70 75% 97% 82% 100%
Kitamura A et al.[10] 343 36% 97% 40% 99%
Brevet M et al.[11] 194 76% 100% 67% 100%
Wu SG et al.[12] 143 88 77% 94% 95%
Kozu Y et al.[13] 577 76% 98% 42% 99%
Hofman P et al.[14] 154 24% 98% 55% 97%