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Table 4 Diagnostic power of L858R-specific IHC on score A, B and C

From: Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies

Scoring system Sensitivity Specificity PPV NPV Cohen’s Kappa
A 82% 97% 93% 92% 0.810 (95% CI: 0.701, 0.919)
B 44% 97% 88% 79% 0.470 (95% CI: 0.332, 0.608)
C 69% 74% 55% 83% 0.397 (95% CI: 0.261, 0.533)
  1. IHC indicates immunohistochemistry; PPV, positive predictive value; NPV, negative predictive value.