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Table 4 Diagnostic power of L858R-specific IHC on score A, B and C

From: Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies

Scoring system

Sensitivity

Specificity

PPV

NPV

Cohen’s Kappa

A

82%

97%

93%

92%

0.810 (95% CI: 0.701, 0.919)

B

44%

97%

88%

79%

0.470 (95% CI: 0.332, 0.608)

C

69%

74%

55%

83%

0.397 (95% CI: 0.261, 0.533)

  1. IHC indicates immunohistochemistry; PPV, positive predictive value; NPV, negative predictive value.
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Diagnostic Pathology

ISSN: 1746-1596

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