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Table 5 Diagnostic power of E746_A750del-specific IHC on score A, B and C

From: Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies

Scoring system Sensitivity Specificity PPV NPV Cohen’s Kappa
A 59% 100% 100% 82% 0.653 (95% CI: 0.521, 0.785)
B 41% 100% 100% 77% 0.480 (95% CI: 0.342, 0.618)
C 53% 91% 75% 79% 0.472 (95% CI: 0.334, 0.610)
  1. IHC indicates immunohistochemistry; PPV, positive predictive value; NPV, negative predictive value.
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Diagnostic Pathology

ISSN: 1746-1596

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