Right-sided rhabdoid colorectal tumors might be related to the Serrated Pathway

Diagnostic Pathology

Table 1 Comparison of immunohistochemical markers between adjacent normal mucosa, tubular adenomas and RCT

(+++): widespread occurrence, intense expression; (++): Varying distribution, moderate expression; (+): Limited occurrence, low expression; (−) no occurrence or negative. ^aβ-catenin nuclear localization; Abbreviations: Cytokeratin, CK; pure rhabdoid colorectal tumor, case I (RCTI); glandular (GC) and rhabdoid (RC) components of composite rhabdoid colorectal tumor, case II (RCTII); adjacent tubular adenomas (TA), cancerized and larger tubular adenoma (CTA) or normal mucosa (NM2) of case II. Case I, a pure RCT, is compared to the adjacent distant non-neoplastic mucosa (NM1); histone deacetylase, HDAC; vascular endothelial growth factor receptors, VEGFR; thymidylate synthase, TS.

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