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Table 5 CD44 expression stratified by the MYCN amplification status in relation to other histoclinical parameters of pNTs

From: Immunohistochemical expression of CD44s in human neuroblastic tumors: Moroccan experience and highlights on current data

  MYCN amplified P value MYCN nonamplified P value
CD44 positive CD44 negative CD44 positive CD44 negative
No. (%) No. (%) No. (%) No. (%)
Age (months)       
< 18 1 (20) 4 (80) 1** 4 (80) 1 (20) 1**
≥ 18 2 (40) 3 (60) 10 (66.7) 5 (33,3)
INSS stages       
I, II, IVs 1 (100) 0 (0) 0,3 8 (100) 0 (0) 0,046
III, IV 2 (22.2) 7 (77,8) 7 (53.8) 6 (46,2)
Metastasis       
Presence 2 (25) 6 (75) 1 6 (50) 6 (50) 0,019
Absence 1 (50) 1 (50) 9 (100) 0 (0)
Differentiation level       
Undifferentiated 3 (30) 7 (70) - 5 (55.6) 4 (44.4) 0,33
Differentiated 0 (0) 0 (0)   10 (83.3) 2 (16.7)  
Shimada category       
Favorable histology 1 (50) 1 (50) 1 11 (100) 0 (0) 0.004
Unfavorable histology 2 (25) 6 (75) 4 (40) 6 (60)
MKI Index       
High 1 (50) 1 (50) 0.645* 5 (71,4) 2 (28.6) 0.262*
Intermediate 0 (0) 2 (100) 2 (50) 2 (50)
Low 1 (25) 3 (75)   1 (33.3) 2 (66.7)  
  1. * chi square for linear trend.
  2. ** Fisher exact test.