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Table 1 Comparison of volume, pH and biochemical parameters of saliva in cystic fibrosis patients and healthy controls

From: Saliva as a potential tool for cystic fibrosis diagnosis

Parameter

CF patients (n=80)

Healthy subjects (n=84)

p-value***

p-value corrected by Bonferroni test

 

Mean ± SD (95% CI)

Median

Mean ± SD (95% CI)

Median

  

Calcium*

2.03± 0.99 (0.30 – 4.65)

1.85

2.15 ± 2.79 (0.71 – 23)

1.61

0.114

1

Glucose*

13.02 ± 18.69 (3 – 147)

8

9.25± 3.56 (3 – 20)

9.5

0.932

1

Lactate*

0.91 ± 0,89 (0.2 – 5.6)

0.7

0.81± 0.74 (0.1 – 4.3)

0.6

0.463

1

Chloride*

27.82 ± 13.47 (12 – 89)

26

18.04 ± 8.3 (8 – 43)

16

<0.001

<0.009

Volume**

0.63 ± 0.3 (0.1– 1.5)

0.6

0.8 ± 0.5 (0 – 2)

1

<0.001

<0.009

Ph

6.86 ± 0.45 (6.27 – 7.8)

6.83

7.17 ± 0,44 (6.3 – 7.85)

7.2

<0.001

<0.009

Potassium*

19.66± 3.25 (10.8 – 24.8)

19.55

16.82 ± 3.22 (6.5 -24)

17.20

<0.001

<0.009

Sodium*

19.90 ± 9.3 (8 – 48)

17.5

12.26 ± 4.31 (7 – 29)

11

<0.001

<0.009

Bicarbonate*

5.53 ± 3.98 (0 – 22)

3

3.58 ± 3.98 (0 -16)

1.95

0.051

0.459

  1. CF – Cystic Fibrosis, CI – Confidential interval, n – number of patients, SD – Standard Deviation.
  2. * mmol/L.
  3. ** N for volume is 68 in CF patients and 64 in healthy subjects, unlike the other parameters.
  4. *** The Statistical analyses were performed by Mann-Whitney test. The positive p-value is in bold.