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Table 1 The correlation between HER2 expression status and clinicopathological parameters

From: HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population

 

Overall

HER2

HER2-

HER2-

 
  

Overexpression

Equivocal

Negative

P value

Pathologic feature

n=1463

n=143 (%)

n=211 (%)

n=1109 (%)

 

Age at diagnosis

    

0.102

≥60 years

683

80 (11.7)

108 (15.8)

495 (72.5)

 

<60 years

780

63 (8.1)

103 (13.2)

614 (78.7)

 

Sex

    

0.344

Male

1104

109 (9.9)

171 (15.5)

824 (74.6)

 

Female

359

34 (9.5)

40 (11.1)

285 (79.4)

 

Tumor location

    

0.003

GC

929

65 (7.0)

121 (13.0)

743 (80.0)

 

GEJ

534

78 (14.6)

90 (16.9)

366 (68.5)

 

Tumor subtype

     

(Lauren classification)

   

0.000

 Intestinal

650

109 (16.8)

111 (17.1)

430 (66.2)

 

 Diffuse

564

13 (2.3)

63 (11.2)

488 (86.5)

 

 Mixed

249

21 (8.4)

37 (14.9)

191 (76.7)

 

Tumor differentiation

    

0.000

 Well

25

4 (16)

9 (36)

12 (48)

 

 Moderately

369

74 (20.1)

70 (19.0)

225 (61.0)

 

 Poorly

1069

65 (6.1)

132 (12.3)

872 (81.6)

 

pT status

    

0.053

 pT1

206

16 (7.8)

33 (16.0)

157 (76.2)

 

 pT2

147

23 (15.6)

28 (19.0)

96 (65.3)

 

 pT3

1074

102 (9.5)

145 (13.5)

827 (77.0)

 

 pT4

36

2 (5.6)

5 (13.9)

29 (80.6)

 

pN status

    

0.074

 pN0

411

39 (9.5)

66 (16.1)

306 (74.5)

 

 pN1

235

27 (11.5)

42 (17.9)

166 (70.6)

 

 pN2

306

20 (6.5)

42 (13.7)

244 (79.7)

 

 pN3

511

57 (11.2)

61 (11.9)

393 (76.9)

 

pM status

    

0.571

 pM0

1429

140 (9.8)

119 (8.3)

1080 (75.6)

 

 pM1

34

3 (8.8)

2 (5.9)

29 (85.3)

 

pTNM stages

    

0.327

 IA

162

14 (8.6)

29 (17.9)

119 (73.5)

 

 IB

93

8 (8.6)

17 (18.3)

68 (73.1)

 

 IIA

201

25 (12.4)

33 (16.4)

143 (71.1)

 

 IIB

230

25 (10.9)

34 (14.8)

171 (74.3)

 

 IIIA

264

15 (5.7)

37 (14.8)

212 (80.3)

 

 IIIB

455

51 (11.2)

56 (12.3)

348 (76.5)

 

 IIIC

24

2 (8.3)

3 (12.5)

19 (79.2)

 

 IV

34

3 (8.8)

2 (5.9)

29 (85.3)

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