| Overall | HER2 | HER2- | HER2- |  |
---|---|---|---|---|---|
 |  | Overexpression | Equivocal | Negative | P value |
Pathologic feature | n=1463 | n=143 (%) | n=211 (%) | n=1109 (%) | Â |
Age at diagnosis | Â | Â | Â | Â | 0.102 |
≥60 years | 683 | 80 (11.7) | 108 (15.8) | 495 (72.5) |  |
<60 years | 780 | 63 (8.1) | 103 (13.2) | 614 (78.7) | Â |
Sex | Â | Â | Â | Â | 0.344 |
Male | 1104 | 109 (9.9) | 171 (15.5) | 824 (74.6) | Â |
Female | 359 | 34 (9.5) | 40 (11.1) | 285 (79.4) | Â |
Tumor location | Â | Â | Â | Â | 0.003 |
GC | 929 | 65 (7.0) | 121 (13.0) | 743 (80.0) | Â |
GEJ | 534 | 78 (14.6) | 90 (16.9) | 366 (68.5) | Â |
Tumor subtype | Â | Â | Â | Â | Â |
(Lauren classification) | Â | Â | Â | 0.000 | |
 Intestinal | 650 | 109 (16.8) | 111 (17.1) | 430 (66.2) |  |
 Diffuse | 564 | 13 (2.3) | 63 (11.2) | 488 (86.5) |  |
 Mixed | 249 | 21 (8.4) | 37 (14.9) | 191 (76.7) |  |
Tumor differentiation | Â | Â | Â | Â | 0.000 |
 Well | 25 | 4 (16) | 9 (36) | 12 (48) |  |
 Moderately | 369 | 74 (20.1) | 70 (19.0) | 225 (61.0) |  |
 Poorly | 1069 | 65 (6.1) | 132 (12.3) | 872 (81.6) |  |
pT status | Â | Â | Â | Â | 0.053 |
 pT1 | 206 | 16 (7.8) | 33 (16.0) | 157 (76.2) |  |
 pT2 | 147 | 23 (15.6) | 28 (19.0) | 96 (65.3) |  |
 pT3 | 1074 | 102 (9.5) | 145 (13.5) | 827 (77.0) |  |
 pT4 | 36 | 2 (5.6) | 5 (13.9) | 29 (80.6) |  |
pN status | Â | Â | Â | Â | 0.074 |
 pN0 | 411 | 39 (9.5) | 66 (16.1) | 306 (74.5) |  |
 pN1 | 235 | 27 (11.5) | 42 (17.9) | 166 (70.6) |  |
 pN2 | 306 | 20 (6.5) | 42 (13.7) | 244 (79.7) |  |
 pN3 | 511 | 57 (11.2) | 61 (11.9) | 393 (76.9) |  |
pM status | Â | Â | Â | Â | 0.571 |
 pM0 | 1429 | 140 (9.8) | 119 (8.3) | 1080 (75.6) |  |
 pM1 | 34 | 3 (8.8) | 2 (5.9) | 29 (85.3) |  |
pTNM stages | Â | Â | Â | Â | 0.327 |
 IA | 162 | 14 (8.6) | 29 (17.9) | 119 (73.5) |  |
 IB | 93 | 8 (8.6) | 17 (18.3) | 68 (73.1) |  |
 IIA | 201 | 25 (12.4) | 33 (16.4) | 143 (71.1) |  |
 IIB | 230 | 25 (10.9) | 34 (14.8) | 171 (74.3) |  |
 IIIA | 264 | 15 (5.7) | 37 (14.8) | 212 (80.3) |  |
 IIIB | 455 | 51 (11.2) | 56 (12.3) | 348 (76.5) |  |
 IIIC | 24 | 2 (8.3) | 3 (12.5) | 19 (79.2) |  |
 IV | 34 | 3 (8.8) | 2 (5.9) | 29 (85.3) |  |