Histopathological examinations of central coagulation necrosis area in patient with invasive pulmonary mucormycosis. (A, B, and C) Histological examination of the surgical specimen presenting reversed halo sigh revealed pulmonary mucormycosis showing irregular, broad-based, and non septated hyphae with branching. Massive angioinvasion was observed in the coagulation necrosis background and alveolar septa and air content was remained. The dagger (†) sign is placed on the areas of ground-glass opacity on computed tomography image. (Photomicrographs stained with hematoxylin and eosin double, Elastica van Gieson, and Grocott stains, respectively. Scale bars represent 100 μm).