Histopathological examinations of central coagulation necrosis area in patient with invasive pulmonary aspergillosis. (A, B, and C) Histological examination of the lung tissue from autopsied patients with invasive pulmonary aspergillosis revealed pulmonary aspergillosis showing Y-shape hyphae with septa. Massive angioinvasion was observed in the coagulation necrosis background. Since alveolar space was filled by plasma exudation, the air content was not remained (Photomicrographs stained with hematoxylin and eosin, Elastica van Gieson, and Grocott stains, respectively. Scale bars represent 1000 μm).