Quantitative assessment of the association between MHTFR C677T (rs1801133, Ala222Val) polymorphism and susceptibility to bladder cancer

Table 1 Main characteristics of these studies included in this meta-analysis

First author [Reference]	Year	Ethnicity	Sample size		Source of control	Cases			Controls			HWE
			Sample size			Ala/Ala	Ala/Val	Val/Val	Ala/Ala	Ala/Val	Val/Val
			case	control		Ala/Ala	Ala/Val	Val/Val	Ala/Ala	Ala/Val	Val/Val
Kimura [15]	2001	Caucasian	165	150	HB	70	80	15	65	73	12	0.17
Sanyal [16]	2004	Caucasian	309	246	PB	173	113	23	121	102	23	0.82
Lin ¹[17]	2004	Caucasian	410	410	PB	176	183	51	196	164	50	0.09
Moore [18]	2004	Caucasian	106	109	PB	45	42	19	32	59	18	0.29
Lin ²[17]	2004	Mixed	17	17	PB	16	1	0	13	4	0	0.58
Lin ³[17]	2004	African	21	21	PB	7	13	1	9	9	3	0.76
Karagas [19]	2005	Caucasian	352	551	PB	140	171	39	227	245	71	0.70
Moore [20]	2006	Asian	1041	1049	PB	418	478	145	402	486	161	0.48
Ouerhani [21]	2007	African	111	131	HB	43	58	10	58	56	17	0.55
Wang [22]	2009	Asian	239	250	PB	66	129	45	88	132	30	0.07
Ouerhani [23]	2009	African	90	110	HB	33	50	7	51	45	14	0.42
Rouissi [24]	2009	African	185	191	HB	87	86	12	81	90	20	0.49
Cai [25]	2009	Asian	312	325	HB	82	169	61	113	170	42	0.08
Safarinejad [26]	2011	Asian	158	316	HB	67	74	17	144	142	30	0.56
Izmirli [27]	2011	Asian	54	50	HB	28	22	4	36	14	0	0.25

HB:Hospital-Based Study. PB: Population-Based Study. HWE: Hardy–Weinberg equilibrium. ^1,2,3: Different descent populations in one publication.

ISSN: 1746-1596