Table 2 Meta-analysis on the association between MTHFR Ala222Val polymorphism and bladder cancer risk
Variables | Study number | Sample size | Test of heterogeneity | Test of Association | |||
|---|---|---|---|---|---|---|---|
case | control | P h | I 2 | OR(95% CL) | P | ||
Ala/Ala vs Val/Val | |||||||
Total | 15 | 3570 | 3926 | 0.04 | 44.3% | 0.96 (0.76 1.21) | 0.73 |
Ethnicity | |||||||
Caucasian | 5 | 1342 | 1466 | 0.70 | 0.0% | 1.07 (0.83 1.38) | 0.59 |
Asian | 5 | 1804 | 1990 | 0.00 | 74.3% | 0.68 (0.41 1.12) | 0.13 |
African | 4 | 407 | 453 | 0.91 | 0.0% | 1.50 (0.91 2.45) | 0.11 |
Mixed population | 1 | 17 | 17 | — | — | — | — |
Source of control | |||||||
HB | 7 | 1075 | 1273 | 0.07 | 49.3% | 0.90 (0.58 1.39) | 0.62 |
PB | 8 | 2495 | 2653 | 0.14 | 37.5% | 1.20 (0.79 1.31) | 0.88 |
Ala/Ala vs Ala/Val | |||||||
Total | 15 | 3570 | 3926 | 0.05 | 41.3% | 0.92 (0.80 1.06) | 0.24 |
Ethnicity | |||||||
Caucasian | 5 | 1342 | 1466 | 0.05 | 58.9% | 1.05 (0.81 1.37) | 0.70 |
Asian | 5 | 1804 | 1990 | 0.15 | 40.4% | 0.86 (0.69 1.06) | 0.15 |
African | 4 | 407 | 453 | 0.26 | 25.9% | 0.80 (0.56 1.13) | 0.20 |
Mixed population | 1 | 17 | 17 | — | — | 4.92 (0.49 49.61) | 0.18 |
Source of control | |||||||
HB | 7 | 1075 | 1273 | 0.40 | 3.7% | 0.82 (0.68 0.98) | 0.03 |
PB | 8 | 2495 | 2653 | 0.04 | 51.5% | 1.01 (0.82 1.23) | 0.94 |
Ala/Val vs Val/Val | |||||||
Total | 15 | 3570 | 3926 | 0.22 | 21.5% | 1.02 (0.85 1.23) | 0.81 |
Ethnicity | |||||||
Caucasian | 5 | 1342 | 1466 | 0.69 | 0.0% | 1.07 (0.83 1.37) | 0.60 |
Asian | 5 | 1804 | 1990 | 0.18 | 36.0% | 0.84 (0.63 1.12) | 0.24 |
African | 4 | 407 | 453 | 0.86 | 0.0% | 1.86 (1.14 3.03) | 0.01 |
Mixed population | 1 | 17 | 17 | — | — | — | — |
Source of control | |||||||
HB | 7 | 1075 | 1273 | 0.14 | 38.6% | 1.08 (0.73 1.59) | 0.71 |
PB | 8 | 2495 | 2653 | 0.35 | 10.7% | 1.03 (0.85 1.25) | 0.76 |
Dominant model | |||||||
Total | 15 | 3570 | 3926 | 0.12 | 32.3% | 1.00 (0.87 1.15) | 0.98 |
Ethnicity | |||||||
Caucasian | 5 | 1342 | 1466 | 0.86 | 0.0% | 1.07 (0.84 1.35) | 0.58 |
Asian | 5 | 1804 | 1990 | 0.03 | 63.4% | 0.77 (0.52 1.12) | 0.17 |
African | 4 | 407 | 453 | 0.94 | 0.0% | 1.68 (1.05 2.69) | 0.03 |
Mixed population | 1 | 17 | 17 | — | — | — | — |
Source of control | |||||||
HB | 7 | 1075 | 1273 | 0.09 | 46.0% | 1.00 (0.67 1.49) | 0.99 |
PB | 8 | 2495 | 2653 | 0.29 | 18.4% | 1.03 (0.84 1.25) | 0.80 |
Recessive model | |||||||
Total | 15 | 3570 | 3926 | 0.02 | 49.1% | 0.92 (0.79 1.07) | 0.28 |
Ethnicity | |||||||
Caucasian | 5 | 1342 | 1466 | 0.07 | 54.4% | 1.06 (0.83 1.34) | 0.66 |
Asian | 5 | 1804 | 1990 | 0.02 | 67.0% | 0.79 (0.60 1.04) | 0.09 |
African | 4 | 407 | 453 | 0.33 | 12.9% | 0.90 (0.67 1.21) | 0.49 |
Mixed population | 1 | 17 | 17 | — | — | 4.92 (0.49 49.61) | 0.18 |
Source of control | |||||||
HB | 7 | 1075 | 1273 | 0.20 | 29.8% | 0.92 (0.66 1.01) | 0.06 |
PB | 8 | 2495 | 2653 | 0.04 | 53.5% | 1.01 (0.83 1.23) | 0.90 |
Ala-allele vs Val-allele | |||||||
Total | 15 | 3570 | 3926 | 0.01 | 50.5% | 0.96 (0.86 1.07) | 0.43 |
Ethnicity | |||||||
Caucasian | 5 | 1342 | 1466 | 0.26 | 23.8% | 1.03 (0.90 1.18) | 0.66 |
Asian | 5 | 1804 | 1990 | 0.00 | 76.5% | 0.81 (0.65 1.03) | 0.08 |
African | 4 | 407 | 453 | 0.65 | 0.0% | 1.05 (0.86 1.29) | 0.63 |
Mixed population | 1 | 17 | 17 | — | — | 4.40 (0.47 41.60) | 0.20 |
Source of control | |||||||
HB | 7 | 1075 | 1273 | 0.07 | 48.0% | 0.89 (0.74 1.06) | 0.19 |
PB | 8 | 2495 | 2653 | 0.07 | 47.3% | 1.01 (0.89 1.15) | 0.89 |