Table 3 The genotype distributions and allele frequencies of the studiedpolymorphisms between patients and controls, and their risk predictionfor CD under three genetic models of inheritance
Polymorphism | CD group (%) | Healthy control (%) | χ 2 | P † | allele | CD group (%) | Healthy control (%) | χ 2 | P ‡ | CD group HWe Pb | Healthy control HWe Pb | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs2293152 | GG | 58 (25.2) | 78 (28.7) | G | 253(55.0) | 292(53.7) | ||||||
CG | 137 (59.6) | 136(50) | 5.16 | 0.08 | C | 207(45.0) | 252(46.3) | 0.18 | 0.67 | 0.21 | 0.93 | |
CC | 35 (15.2) | 58 (21.3) | ||||||||||
OR; 95% CI; P | Additive model: 094; (0.73,1.23); 0.66 | Dominant model: 1.19; (0.8,1.77); 0.39 | Recessive model: 0.66; (0.42,1.05); 0.08 | |||||||||
rs4796793 | CC | 111 (47.8) | 112 (41.2) | C | 324 (69.8) | 345 (63.4) | ||||||
CG | 102 (44.0) | 121 (44.5) | 5.38 | 0.07 | G | 140(30.2) | 199 (36.6) | 4.61 | 0.03 | 0.51 | 0.50 | |
GG | 19 (8.2) | 39 (14.3) | ||||||||||
OR; 95% CI; P | Additive model: 075; (0.58,0.98); 0.03 | Dominant model: 0.76; (0.57,1.09); 0.13 | Recessive model: 0.53; (0.30,0.95); 0.03 | |||||||||
rs744166 | TT | 106(48) | 98 (36.2) | T | 309 (69.9) | 323 (59.6) | ||||||
CT | 97(43.9) | 127 (46.9) | 11.62 | 0.003 | C | 133 (30.1) | 219 (40.4) | 11.28 | 0.0008 | 0.52 | 0.66 | |
CC | 18 (8.1) | 46 (16.9) | ||||||||||
OR; 95% CI; P | Additive model: 063; (0.48,0.83); <0.001 | Dominant model: 0.61; (0.43,0.81); 0.008 | Recessive model: 0.43; (0.24,0.77); 0.005 | |||||||||