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Table 3 The genotype distributions and allele frequencies of the studiedpolymorphisms between patients and controls, and their risk predictionfor CD under three genetic models of inheritance

From: Association between STAT3 gene Polymorphisms and Crohn’s diseasesusceptibility: a case–control study in a Chinese Han population

Polymorphism CD group (%) Healthy control (%)  χ 2  P † allele CD group (%) Healthy control (%)  χ 2  P ‡ CD group HWe Pb Healthy control HWe Pb
rs2293152 GG 58 (25.2) 78 (28.7)    G 253(55.0) 292(53.7)     
CG 137 (59.6) 136(50) 5.16 0.08 C 207(45.0) 252(46.3) 0.18 0.67 0.21 0.93
CC 35 (15.2) 58 (21.3)          
OR; 95% CI; P Additive model: 094; (0.73,1.23); 0.66 Dominant model: 1.19; (0.8,1.77); 0.39 Recessive model: 0.66; (0.42,1.05); 0.08
rs4796793 CC 111 (47.8) 112 (41.2)    C 324 (69.8) 345 (63.4)     
  CG 102 (44.0) 121 (44.5) 5.38 0.07 G 140(30.2) 199 (36.6) 4.61 0.03 0.51 0.50
  GG 19 (8.2) 39 (14.3)          
OR; 95% CI; P Additive model: 075; (0.58,0.98); 0.03 Dominant model: 0.76; (0.57,1.09); 0.13 Recessive model: 0.53; (0.30,0.95); 0.03
rs744166 TT 106(48) 98 (36.2)    T 309 (69.9) 323 (59.6)     
  CT 97(43.9) 127 (46.9) 11.62 0.003 C 133 (30.1) 219 (40.4) 11.28 0.0008 0.52 0.66
  CC 18 (8.1) 46 (16.9)          
OR; 95% CI; P Additive model: 063; (0.48,0.83); <0.001 Dominant model: 0.61; (0.43,0.81); 0.008 Recessive model: 0.43; (0.24,0.77); 0.005
  1. Abbreviations: HWe Hardy-Weinberg equilibrium. P values were calculated usingχ2 test 3 × 2 contingency table (†) forgenotype distributions and 2 × 2 contingency table(‡) for allele distributions.OR, 95%CI and P values werecalculated by logistic regression analysis.
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Diagnostic Pathology

ISSN: 1746-1596

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