Table 1 Characteristics of studies included in this meta-analysis
First author (Year) | Ethnicity | Sample size (case/control) | Genotyping methods | Matching criteria | Source of control | BC confirmation | Quality scores | SNP studied | HWE(P value) | |
|---|---|---|---|---|---|---|---|---|---|---|
Ser326Cys | Asp148Glu | |||||||||
Vogel [31] | Caucasian | 425/434 | Sequencing | Age, menopausal status | PB | NA | 7 | OGG1 Ser326Cys | 0.175 | — |
Choi [32] | Asian | 265/284 | PCR-RFLP | NA | HB | Histopatho- | 6.5 | OGG1 Ser326Cys | 0.048 | — |
Choi [32] | Asian | 201/184 | PCR-CTPP | Age | HB | Histo- | 6 | OGG1 Ser326Cys | 0.914 | — |
Huang [16] | Asian | 136/232 | PCR-RFLP | Age | HB | Patho- | 6 | OGG1 Ser326Cys APEX1 Asp148Glu | 0.525 | 0.565 |
Zhang [33] | Caucasian | 1571/1244 | TaqMan | Age | PB | NA | 8 | OGG1 Ser326Cys APEX1 Asp148Glu | 0.930 | 0.456 |
Rossner [34] | Caucasian | 1041/1093 | FP-TDI | Age | PB | NA | 8 | OGG1 Ser326Cys | 0.857 | — |
Cai [35] | Asian | 1102/1167 | TaqMan | Age | PB | NA | 8 | OGG1 Ser326Cys | 0.080 | — |
Synowiec [36] | Caucasian | 41/48 | PCR-RFLP | Age | HB | NA | 2.5 | OGG1 Ser326Cys | 0.507 | — |
Sangrajrang [37] | Asian | 506/424 | Capillary PCR | Region, menopausal status, drinking, smoking | HB | Histo- | 7 | OGG1 Ser326Cys APEX1 Asp148Glu | 0.627 | 0.135 |
Romanowicz-Makowska [38] | Caucasian | 100/106 | PCR-RFLP | Age | HB | NA | 2.5 | OGG1 Ser326Cys | 0.988 | — |
Loizidou [39] | Caucasian | 1108/1174 | TaqMan | Age | PB | Patho- | 9.5 | OGG1 Ser326Cys | 0.499 | — |
Sterpone [28] | Caucasian | 43/34 | PCR-SSCP | Age, gender | HB | NA | 3 | OGG1 Ser326Cys | 0.577 | — |
Ming-Shiean [41] | Asian | 401/533 | TaqMan | Age | HB | Patho- | 6.5 | OGG1 Ser326Cys | 0.034 | — |
Roberts [20] | Caucasian | 1054/1887 | MALDI-TOF | Age, race | PB | Histo- | 8 | OGG1 Ser326Cys | 0.543 | — |
Smolarz [22] | Caucasian | 70/70 | PCR-RFLP | Age | HB | Histo- | 5 | OGG1 Ser326Cys | 0.473 | — |
Kim [17] | Asian | 346/351 | ASPE | Age, BMI, smoking, drinking | HB | Histo- | 6.5 | OGG1 Ser326Cys APEX1 Asp148Glu | 0.296 | 0.012 |
Xie [21] | Asian | 630/777 | Sequencing | Age, BMI, menopausal status | HB | Patho- | 7 | OGG1 Ser326Cys | 0.161 | — |
Smith [42] | Caucasian | 319/405 | TaqMan | Age, race | HB | Histopatho- | 7 | APEX1 Asp148Glu | — | 0.507 |
Smith [42] | African | 53/75 | TaqMan | Age, race | HB | Histopatho- | 6 | APEX1 Asp148Glu | — | 0.566 |
Jelonek [43] | Caucasian | 91/412 | PCR-RFLP | Age, gender | PB | NA | 5 | APEX1 Asp148Glu | — | 0.092 |