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Table 1 Characteristics of studies included in this meta-analysis

From: Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis

First author (Year) Ethnicity Sample size (case/control) Genotyping methods Matching criteria Source of control BC confirmation Quality scores SNP studied HWE(P value)
Ser326Cys Asp148Glu
Vogel [31] Caucasian 425/434 Sequencing Age, menopausal status PB NA 7 OGG1 Ser326Cys 0.175
Choi [32] Asian 265/284 PCR-RFLP NA HB Histopatho- 6.5 OGG1 Ser326Cys 0.048
Choi [32] Asian 201/184 PCR-CTPP Age HB Histo- 6 OGG1 Ser326Cys 0.914
Huang [16] Asian 136/232 PCR-RFLP Age HB Patho- 6 OGG1 Ser326Cys APEX1 Asp148Glu 0.525 0.565
Zhang [33] Caucasian 1571/1244 TaqMan Age PB NA 8 OGG1 Ser326Cys APEX1 Asp148Glu 0.930 0.456
Rossner [34] Caucasian 1041/1093 FP-TDI Age PB NA 8 OGG1 Ser326Cys 0.857
Cai [35] Asian 1102/1167 TaqMan Age PB NA 8 OGG1 Ser326Cys 0.080
Synowiec [36] Caucasian 41/48 PCR-RFLP Age HB NA 2.5 OGG1 Ser326Cys 0.507
Sangrajrang [37] Asian 506/424 Capillary PCR Region, menopausal status, drinking, smoking HB Histo- 7 OGG1 Ser326Cys APEX1 Asp148Glu 0.627 0.135
Romanowicz-Makowska [38] Caucasian 100/106 PCR-RFLP Age HB NA 2.5 OGG1 Ser326Cys 0.988
Loizidou [39] Caucasian 1108/1174 TaqMan Age PB Patho- 9.5 OGG1 Ser326Cys 0.499
Sterpone [28] Caucasian 43/34 PCR-SSCP Age, gender HB NA 3 OGG1 Ser326Cys 0.577
Ming-Shiean [41] Asian 401/533 TaqMan Age HB Patho- 6.5 OGG1 Ser326Cys 0.034
Roberts [20] Caucasian 1054/1887 MALDI-TOF Age, race PB Histo- 8 OGG1 Ser326Cys 0.543
Smolarz [22] Caucasian 70/70 PCR-RFLP Age HB Histo- 5 OGG1 Ser326Cys 0.473
Kim [17] Asian 346/351 ASPE Age, BMI, smoking, drinking HB Histo- 6.5 OGG1 Ser326Cys APEX1 Asp148Glu 0.296 0.012
Xie [21] Asian 630/777 Sequencing Age, BMI, menopausal status HB Patho- 7 OGG1 Ser326Cys 0.161
Smith [42] Caucasian 319/405 TaqMan Age, race HB Histopatho- 7 APEX1 Asp148Glu 0.507
Smith [42] African 53/75 TaqMan Age, race HB Histopatho- 6 APEX1 Asp148Glu 0.566
Jelonek [43] Caucasian 91/412 PCR-RFLP Age, gender PB NA 5 APEX1 Asp148Glu 0.092
  1. BC, breast cancer; Histopatho-, Histopathologically confirmed; Histo-, Histologically confirmed; Patho-, Pathologically confirmed; NA, Not available; PB, Population–based; HB, Hospital–based; HWE, Hardy–Weinberg equilibrium in control population; PCR–RFLP, Polymerase chain reaction-restriction fragment length polymorphism; PCR-CTPP, Polymerase chain reaction with confronting two-pair primers; FP-TDI, Template-directed primer extension and detection by fluorescence polarization; PCR-SSCP, Polymerase chain reaction-single strand conformation polymorphism; MALDI-TOF, Matrix-assisted laser desorption/ionization-time of flight mass spectrometry; ASPE, Allele-specific primer extension method.