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Table 2 Meta-analysis of OGG1 Ser326Cys polymorphism and breast cancer risk

From: Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis

Analysis

No. of studies

Cys/Cys vs. Ser/Ser (Homozygote)

Ser/Cys vs. Ser/Ser (Heterozygote)

Cys/Cys + Ser/Cys vs. Ser/Ser (Dominant model)

Cys/Cys vs. Ser/Cys + Ser/Ser (Recessive model)

OR (95% CI)

P/Ph

OR (95% CI)

P/Ph

OR (95% CI)

P/Ph

OR (95% CI)

P/Ph

Overall

17

1.073(0.968-1.190)

0.180/0.485

0.986(0.923-1.054)

0.679/0.594

1.001(0.940-1.067)

0.971/0.501

1.079(0.993-1.172)

0.074/0.580

Ethnicity

         

Caucasian

9

0.956(0.812-1.127)

0.595/0.635

0.964(0.891-1.043)

0.357/0.218

0.967(0.897-1.043)

0.388/0.271

0.995(0.850-1.164)

0.945/0.958

Asian

8

1.157(1.013-1.321)

0.011/0.492

1.043(0.922-1.178)

0.505/0.946

1.085(0.967-1.218)

0.166/0.903

1.113(1.009-1.227)

0.014/0.173

Menopausal status

         

Premenopausal

7

1.153(0.957-1.388)

0.134/0.215

1.030(0.897-1.182)

0.677/0.995

1.052(0.923-1.199)

0.449/0.855

1.175(0.929-1.487)

0.178/0.149

Postmenopausal

9

1.154(0.965-1.380)

0.116/0.710

0.962(0.863-1.072)

0.482/0.202

0.994(0.896-1.102)

0.903/0.351

1.162(1.003-1.346)

0.024/0.570

Quality score

         

>6

11

1.093(0.980-1.218)

0.110/0.845

0.993(0.928-1.063)

0.841/0.941

1.007(0.944-1.075)

0.829/0.912

1.086(0.995-1.186)

0.065/0.507

≤6

6

0.916(0.664-1.262)

0.590/0.110

0.879(0.667-1.159)

0.361/0.157

0.910(0.702-1.180)

0.478/0.170

1.017(0.789-1.310)

0.899/0.446

Source of control

         

HB

11

1.134(0.975-1.320)

0.104/0.164

0.966(0.842-1.107)

0.615/0.384

1.029(0.904-1.170)

0.669/0.238

1.166(0.945-1.307)

0.107/0.462

PB

6

1.023(0.889-1.178)

0.750/0.997

0.992(0.920-1.071)

0.845/0.656

0.993(0.923-1.067)

0.843/0.802

0.987(0.874-1.114)

0.829/0.987

HWE in controls

         

Yes

15

1.071(0.960-1.195)

0.218/0.343

0.989(0.924-1.059)

0.757/0.468

1.002(0.939-1.069)

0.961/0.362

1.068(0.976-1.168)

0.465/0.154

No

2

1.086(0.803-1.471)

0.592/0.993

0.929(0.693-1.244)

0.620/0.717

0.993(0.755-1.307)

0.961/0.765

1.142(0.923-1.413)

0.223/0.726

  1. Ph P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HB, Hospital–based studies; PB, Population-based studies; HWE, Hardy–Weinberg equilibrium.
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Diagnostic Pathology

ISSN: 1746-1596

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