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Table 2 Meta-analysis of OGG1 Ser326Cys polymorphism and breast cancer risk

From: Association between OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and breast cancer risk: a meta-analysis

Analysis No. of studies Cys/Cys vs. Ser/Ser (Homozygote) Ser/Cys vs. Ser/Ser (Heterozygote) Cys/Cys + Ser/Cys vs. Ser/Ser (Dominant model) Cys/Cys vs. Ser/Cys + Ser/Ser (Recessive model)
OR (95% CI) P/Ph OR (95% CI) P/Ph OR (95% CI) P/Ph OR (95% CI) P/Ph
Overall 17 1.073(0.968-1.190) 0.180/0.485 0.986(0.923-1.054) 0.679/0.594 1.001(0.940-1.067) 0.971/0.501 1.079(0.993-1.172) 0.074/0.580
Ethnicity          
Caucasian 9 0.956(0.812-1.127) 0.595/0.635 0.964(0.891-1.043) 0.357/0.218 0.967(0.897-1.043) 0.388/0.271 0.995(0.850-1.164) 0.945/0.958
Asian 8 1.157(1.013-1.321) 0.011/0.492 1.043(0.922-1.178) 0.505/0.946 1.085(0.967-1.218) 0.166/0.903 1.113(1.009-1.227) 0.014/0.173
Menopausal status          
Premenopausal 7 1.153(0.957-1.388) 0.134/0.215 1.030(0.897-1.182) 0.677/0.995 1.052(0.923-1.199) 0.449/0.855 1.175(0.929-1.487) 0.178/0.149
Postmenopausal 9 1.154(0.965-1.380) 0.116/0.710 0.962(0.863-1.072) 0.482/0.202 0.994(0.896-1.102) 0.903/0.351 1.162(1.003-1.346) 0.024/0.570
Quality score          
>6 11 1.093(0.980-1.218) 0.110/0.845 0.993(0.928-1.063) 0.841/0.941 1.007(0.944-1.075) 0.829/0.912 1.086(0.995-1.186) 0.065/0.507
≤6 6 0.916(0.664-1.262) 0.590/0.110 0.879(0.667-1.159) 0.361/0.157 0.910(0.702-1.180) 0.478/0.170 1.017(0.789-1.310) 0.899/0.446
Source of control          
HB 11 1.134(0.975-1.320) 0.104/0.164 0.966(0.842-1.107) 0.615/0.384 1.029(0.904-1.170) 0.669/0.238 1.166(0.945-1.307) 0.107/0.462
PB 6 1.023(0.889-1.178) 0.750/0.997 0.992(0.920-1.071) 0.845/0.656 0.993(0.923-1.067) 0.843/0.802 0.987(0.874-1.114) 0.829/0.987
HWE in controls          
Yes 15 1.071(0.960-1.195) 0.218/0.343 0.989(0.924-1.059) 0.757/0.468 1.002(0.939-1.069) 0.961/0.362 1.068(0.976-1.168) 0.465/0.154
No 2 1.086(0.803-1.471) 0.592/0.993 0.929(0.693-1.244) 0.620/0.717 0.993(0.755-1.307) 0.961/0.765 1.142(0.923-1.413) 0.223/0.726
  1. Ph P values of Q-test for heterogeneity test. OR, odds ratio; CI, confidence intervals; HB, Hospital–based studies; PB, Population-based studies; HWE, Hardy–Weinberg equilibrium.