Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis

Diagnostic Pathology

Table 2 Meta-analysis of the associations between CYP1B1 L432V polymorphism and urinary cancer risk

Cancer	Number of studies	Cases/controls	Comparison	Test of association			Test of heterogeneity			Publication bias
				OR	95% CI	P Value	Q	P Value	I²(%)	P Value (Begg’s)
Prostate	10	5949/5388	CC vs GG	0.942	0.868-1.022	0.151	20.23	0.017	55.5	0.917
			CC vs CG	0.947	0.881-1.018	0.137	23.13	0.006	61.1	0.212
			CC vs CG + GG	0.952	0.895-1.013	0.120	20.00	0.018	55.0	0.671
			C vs G	0.963	0.920-1.008	0.108	24.36	0.004	63.0	0.723
Bladder	5	1658/1593	CC vs GG	1.061	0.962-1.171	0.234	2.23	1	0.0	0.035
			CC vs CG	1.000	0.926-1.079	0.991	7.20	0.126	44.4	0.317
			CC vs CG + GG	1.016	0.947-1.090	0.661	6.25	0.181	36.0	0.156
			C vs G	1.026	0.977-1.077	0.312	3.75	0	0.0	0.060
Renal	2	337/408	CC vs GG	0.740	0.593-0.922	0.007	0.73	0.394	0	-
			CC vs CG	0.816	0.686-0.969	0.021	1.34	0.248	25.2	-
			CC vs CG + GG	0.787	0.673-0.922	0.003	1.35	0.245	26.0	-
			C vs G	0.818	0.729-0.917	0.001	1.82	0.178	45	-
Overall	17	7944/7389	CC vs GG	0.941	0.876-1.012	0.103	35.2	0.004	54.6	0.607
			CC vs CG	0.937	0.881-0.996	0.037	37.29	0.002	57.1	0.076
			CC vs CG + GG	0.942	0.890-0.997	0.038	37.97	0.002	57.9	0.199
			C vs G	0.957	0.917-0.998	0.039	46.07	0	65.3	0.302

ISSN: 1746-1596