From: Heterogenous mismatch-repair status in colorectal cancer
Case | Block no. | Hetero-geneity | Pattern | Involved area (%) | MMR protein immunostaining | Fraction of MSI in markers | MLH1 promoter methylation | |||
---|---|---|---|---|---|---|---|---|---|---|
MLH1 | PMS2 | MSH2 | MSH6 | |||||||
1 | 1A¤/* | + | CL | 15 | +/− | +/− | + | + | 0/5 and 4/5 | +/− |
 | 1B | + | CL | 5 | - | - | +/R | +/− |  |  |
 | 1C | - | H | 0 | - | - | + | + |  |  |
 | 1D | - | H | 0 | - | - | + | + |  |  |
 | 1E¤ | + | CL, IG | 70 / 10 | +/− | +/− | +/R | +/− | 0/3 vs 4/5 |  |
2 | 24 | - | H | 0 | + | + | + | + | Â | - |
 | 25* | - | H | 0 | + | + | + | + | 0/5 |  |
 | 26 | - | H | 0 | + | + | + | + |  |  |
 | 27* | - | H | 0 | + | + | + | + | 0/5 |  |
 | 28 | + | CL, IG | 15 | +/− | +/− | + | + |  |  |
 | 29* | + | CL, IG | 40 | +/− | +/− | + | + | 5/5 |  |
 | 30 | + | IG | 10 | +/− | +/− | + | + |  |  |
 | 31 | + | IG | 5 | +/− | +/− | + | + |  |  |
 | 32 | + | IG | 5 | +/− | +/− | + | + |  |  |
4 | 2 | + | IG | 97 | + | + | +/− | R/- |  | NE |
 | 3¤/* | + | CL, IG | 95 | + | + | +/− | R/- | 3/3 vs 3/5 |  |
 | 4 | + | CL, IG | 80 | + | + | +/− | R/- |  |  |
 | 5* | + | IG | 95 | + | + | +/− | R/- | 5/5 |  |
5 | 20* | + | CL, IG | 50 / 100 | + | +/− | - | R/- | 5/5 | - |
 | 21 | + | IG | 100 | + | + | - | R/- |  |  |
 | 23 | + | IG | 100 | + | + | - | R/- |  |  |
 | 24 | + | IG | 100 | + | + | - | R/- |  |  |
 | 25 | + | COM, IG | 100 | + | - | - | R/- |  |  |
 | 26 | + | COM, IG | 100 | + | - | - | R/- |  |  |
 | 27 | + | COM IG | 100 | + | - | - | R/- |  |  |
 | 28 | + | COM, IG | 100 | + | - | - | R/- |  |  |
 | 29 | + | COM, IG | 100 | + | - | - | R/- |  |  |
 | 30 | + | COM, IG | 100 | + | - | - | R/- |  |  |
 | 31 | + | COM, IG | 100 | + | - | - | R/- |  |  |
6 | 5¤ | + | IG | 100 | + | R/- | + | + | 0/5 vs 0/4 | NE |
 | 6* | + | IG | 100 | + | R/- | + | + | 0/5 |  |
 | 7* | - | H | 0 | + | + | + | + | 0/5 |  |
 | 8* | + | IG | 100 | + | R/- | + | + | 0/5 |  |
 | 9* | + | IG | 95 | + | R/- | + | + | 0/5 |  |
 | 10 | + | IG | 95 | + | R/- | + | + |  |  |
 | 11* | + | IG | 100 | + | R/- | + | + | 0/5 |  |
8 | 5* | - | H | 0 | - | - | + | + | 5/5 | + |
 | 6 | + | CL, IG | 60 | - | - | + | R/- |  |  |
 | 7 | + | CL | 20 | - | - | + | +/− |  |  |
 | 8 | - | H | 0 | - | - | + | + |  |  |
 | 9 | - | H | 0 | - | - | + | + |  |  |
 | 10 | + | CL, IG | 20 | - | - | +/R | +/− |  |  |
 | 11 | - | H | 0 | - | - | + | + |  |  |
 | 12 | + | CL | 20 | - | - | +/− | +/− |  |  |
9 | 16 | - | H | 0 | + | + | + | + | Â | + |
 | 19 | - | H | 0 | + | + | + | + |  |  |
 | 20* | - | H | 0 | + | + | + | + | 0/5 |  |
 | 21* | - | COM | 100 | - | - | + | + | 5/5 |  |
 | 22 | - | H | 0 | + | + | + | + |  |  |
 | 40 | - | H | 0 | + | + | + | + |  |  |
 | 44 | - | H | 0 | + | + | + | + |  |  |
10 | 6 | + | CL | 50 | - | - | +/− | +/− |  | + |
 | 7 | - | H | 0 | - | - | + | + |  |  |
 | 8 | - | H | 0 | - | - | + | + |  |  |
 | 9* | - | H | 0 | - | - | + | + | 5/5 |  |
 | 10 | - | H | 0 | - | - | + | + |  |  |
 | 11 | - | H | 0 | - | - | + | + |  |  |
11 | 3 | - | H | 0 | - | - | + | + | Â | + |
 | 4 | + | CL, IG | 5 | - | - | +/− | +/− |  |  |
 | 5 | - | H | 0 | - | - | + | + |  |  |
 | 6* | - | H | 0 | - | - | + | + | 5/5 |  |
 | 7 | - | H | 0 | - | - | + | + |  |  |
 | 8* | + | CL, IG | 30 | - | - | +/R | +/− | 5/5 |  |
12 | 3* | + | CL | 5 | - | - | +/− | +/− | 5/5 | + |
 | 4 | + | CL, IG | 90 | - | - | +/− | +/− |  |  |
 | 5 | + | CL, IG | 80 | - | - | +/− | +/− |  |  |
 | 6 | - | H | 100 | - | - | - | - |  |  |
 | 7 | + | CL | 60 | - | - | +/− | +/− |  |  |
 | 8 | + | CL, IG | 90 | - | - | +/− | +/− |  |  |
 | 9* | + | CL, IG | 60 | - | - | +/− | +/− | 5/5 |  |
14 | 1A* | - | H | 0 | - | - | + | + | 5/5 | + |
 | 1B* | + | CL | 5 | - | - | +/R | +/− | 5/5 |  |
 | 1C* | + | CL, IG | 30 | - | - | R/- | +/− | 5/5 |  |
 | 1D* | + | CL | 40 | - | - | +/R | +/− | 5/5 |  |
 | 1E* | + | CL, IG | 40 | - | - | R/- | +/− | 5/5 |  |
15 | 4A* | + | IG | 100 | + | + | +/R | R/- | 5/5 | NE |
 | 4B* | + | IG | 100 | + | + | + | R/- | 5/5 |  |
 | 4C | + | IG | 100 | + | + | +/R | R/- |  |  |
 | 4D | + | IG | 100 | + | + | + | R/- |  |  |
 | 4E | + | IG | 100 | + | + | +/R | R/- |  |  |
16 | 6A | + | IG | 15 | - | - | R | +/− |  | + |
 | 6B* | + | CL | 3 | - | - | +/R | +/− | 5/5 |  |
 | 6C | + | CL | 10 | - | - | +/R | +/− |  |  |
 | 6D | + | IG | 5 | - | - | R | +/− |  |  |
 | 6E | + | IG | 5 | - | - | +/R | +/− |  |  |
17 | 18* | + | CL | 55 | - | - | +/− | +/− | 5/5 | + |
 | 19 | - | H | 0 | - | - | + | + |  |  |
 | 20 | + | CL | 8 | - | - | +/− | +/− |  |  |
 | 21 | - | H | 0 | - | - | + | + |  |  |
 | 22 | - | H | 0 | - | - | + | + |  |  |