Table 3 Meta-analyses of TAP2-379, TAP2-565, TAP2-665with RA*
From: Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis
Genetic locus | Cases/controls (S*) | Genetic model | Ethnicity | OR (95% CI) | P value | I2 | Power |
|---|---|---|---|---|---|---|---|
TAP2-379 | 796/677 (8) | Overall ( I vs V) | Overall | 1.44 (1.18-1.74) | 0.0002 | 42% | 0.477 |
| Â | 522/768 (5) | Â | Europeans | 1.39 (0.88-2.20) | 0.16 | 64% | 0.286 |
| Â | 274/293 (3) | Â | Asians | 1.38 (1.04-1.83) | 0.03 | 0% | 0.241 |
| Â | 320/298 (3) | Dominant ( II/IV vs VV ) | Â | 1.59 (1.14-2.22) | 0.006 | 0% | 0.336 |
| Â | 320/298 (3) | Recessive ( II vs IV/VV ) | Â | 1.24 (0.58-2.64) | 0.58 | 0% | 0.104 |
| Â | 198/209 (3) | Additive ( II vs VV ) | Â | 1.49 (0.68-3.23) | 0.32 | 0% | 0.101 |
TAP2-565 | 891/871 (8) | Overall ( T vs A ) | Overall | 1.23 (0.84-1.81) | 0.28 | 64% | 0.439 |
| Â | 522/778 (5) | Â | Europeans | 1.62 (1.20-2.20) | 0.002 | 24% | 0.229 |
| Â | 369/482 (3) | Â | Asians | 0.87 (0.43-1.75) | 0.70 | 76% | 0.254 |
| Â | 415/487 (3) | Dominant ( TT/TA vs AA ) | Â | 1.17 (0.85-1.61) | 0.33 | 45% | 0.379 |
| Â | 415/487 (3) | Recessive ( TT vs TA/AA ) | Â | 4.71 (0.51-43.33) | 0.17 | 64% | 0.075 |
| Â | 335/384 (3) | Additive ( TT vs AA ) | Â | 4.64 (0.52-41.77) | 0.17 | 64% | 0.075 |
TAP2-665 | 714/578 (7) | Overall ( A vs T ) | Overall | 1.02 (0.85-1.22) | 0.84 | 48% | 0.557 |
| Â | 522/384 (5) | Â | Europeans | 0.87 (0.69-1.09) | 0.23 | 39% | 0.475 |
| Â | 192/194 (2) | Â | Asians | 1.32 (0.99-1.77) | 0.06 | 0% | 0.080 |
| Â | 238/199 (2) | Dominant ( AA/AT vs TT ) | Â | 1.07 (0.44-2.57) | 0.88 | 67% | 0.252 |
| Â | 238/199 (2) | Recessive ( AA vs AT/TT ) | Â | 0.58 (0.06-5.77) | 0.64 | 77% | 0.131 |
| Â | 128/100 (2) | Additive ( AA vs TT ) | Â | 1.15 (0.53-2.49) | 0.73 | 83% | 0.122 |