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Table 3 Meta-analyses of TAP2-379, TAP2-565, TAP2-665with RA*

From: Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis

Genetic locus Cases/controls (S*) Genetic model Ethnicity OR (95% CI) P value I2 Power
TAP2-379 796/677 (8) Overall ( I vs V) Overall 1.44 (1.18-1.74) 0.0002 42% 0.477
  522/768 (5)   Europeans 1.39 (0.88-2.20) 0.16 64% 0.286
  274/293 (3)   Asians 1.38 (1.04-1.83) 0.03 0% 0.241
  320/298 (3) Dominant ( II/IV vs VV )   1.59 (1.14-2.22) 0.006 0% 0.336
  320/298 (3) Recessive ( II vs IV/VV )   1.24 (0.58-2.64) 0.58 0% 0.104
  198/209 (3) Additive ( II vs VV )   1.49 (0.68-3.23) 0.32 0% 0.101
TAP2-565 891/871 (8) Overall ( T vs A ) Overall 1.23 (0.84-1.81) 0.28 64% 0.439
  522/778 (5)   Europeans 1.62 (1.20-2.20) 0.002 24% 0.229
  369/482 (3)   Asians 0.87 (0.43-1.75) 0.70 76% 0.254
  415/487 (3) Dominant ( TT/TA vs AA )   1.17 (0.85-1.61) 0.33 45% 0.379
  415/487 (3) Recessive ( TT vs TA/AA )   4.71 (0.51-43.33) 0.17 64% 0.075
  335/384 (3) Additive ( TT vs AA )   4.64 (0.52-41.77) 0.17 64% 0.075
TAP2-665 714/578 (7) Overall ( A vs T ) Overall 1.02 (0.85-1.22) 0.84 48% 0.557
  522/384 (5)   Europeans 0.87 (0.69-1.09) 0.23 39% 0.475
  192/194 (2)   Asians 1.32 (0.99-1.77) 0.06 0% 0.080
  238/199 (2) Dominant ( AA/AT vs TT )   1.07 (0.44-2.57) 0.88 67% 0.252
  238/199 (2) Recessive ( AA vs AT/TT )   0.58 (0.06-5.77) 0.64 77% 0.131
  128/100 (2) Additive ( AA vs TT )   1.15 (0.53-2.49) 0.73 83% 0.122
  1. S*: Amount of stages; V: Valine; I: Isoleucine; A: Alanine; T: Threonine.